The compounds are highly selective agonists for the PPAR- gamma receptor or prodrugs of agonists for the PPAR- gamma receptor. Thus these compounds are useful in the treatment Type II diabetes (NIDDM).doi:US6713514KOLB, HARTMUTH, C.MCGEEHAN, GERARD...
Nonsteroidal anti-inflammatory drugs and peroxisome proliferator-activated receptor-gamma agonists modulate immunostimulated processing of amyloid precursor protein through regulation of beta-secretase. J Neurosci 2003;23: 9796–9804. CAS PubMed Google Scholar Sastre M, Dewachter I, Rossner S, et al....
Peroxisome proliferator-activated receptor gamma (PPARɣ) agonists exert powerful anticancer effects by suppressing tumor growth. In this study, we developed PPZ023 (1-(2-(ethylthio)benzyl)-4-(2-methoxyphenyl)piperazine), a novel PPAR ligand candidate, and investigated the underlying signaling path...
ppary中枢神经系统损伤治疗的新作者:单位:邮编:关键词过氧化物酶增殖物激活受体y;中枢神经系统损伤;神经保护过氧化物酶体增殖物激活受体yppary是一类由配体激活的核转 录因子,为核受体超家族中的成员之一。1990年isseman等首次
11. Conclusions and Future Applications of PPAR-Gamma Partial Agonists for Precision Oncology In particular, witnessing the data together tries to update with the scenario that in spite of extensive formulation of ligands for PPAR-γ, the application is limited and largely abandoned by drug companies...
At present, there are barely drugs in the market. In summary, we processed pahrmacophore virtual screening, docking analysis (CDOCKER), ADMET prediction, and molecular dynamics simulation (MDs) to screen the CHEMBL database to find potential dual PPARα/γ agonists in our work. Firstly, we ...
In male ZDF rats, fenofibrate and other PPARα agonists have only a minor effect and part of the reported effects of PPARα agonists on glucose control in male ZDF rats could be related to decreased food intake, which is typical for these drugs in male ZDF rats[21]. PPARγ agonist ...
PPAR-gamma agonists as regulators of microglial activation and brain inflammation. and Minghetti, L. (2006). PPAR-γ agonists as regulators of microglial activation and brain inflammation. Curr. Pharm. Des. 12, 93-109... L Minghetti,A Bernardo - 《Current Pharmaceutical Design》 被引量: 313发...
PPAR agonists are classification of drugs that directly acts on the PPAR. They are beneficial in treating metabolic syndrome as they help in lowering the level of blood sugar and triglycerides. There are various types of PPAR agonist. The PPAR gamma is the primary target of TZDs (thiazolidinedion...
nature publishing group Translational Investigation Articles Nebulized PPARγ agonists: a novel approach to augment neonatal lung maturation and injury repair in rats Edith Morales1,2, Reiko Sakurai1, Sumair Husain1, Dave Paek1, Ming Gong1, Basil Ibe1, Yishi Li1, Maleha Husain...