PPAR-gamma agonistsThe rationale for the treatment of Cushing's disease is to normalize serum cortisol and ACTH levels, while preserving the anterior pituitary function. The treatment of choice for Cushing's disease is surgery. However, in some circumstances the patients can need further treatment ...
Peroxisome proliferator-activated receptor gamma (PPARɣ) agonists exert powerful anticancer effects by suppressing tumor growth. In this study, we developed PPZ023 (1-(2-(ethylthio)benzyl)-4-(2-methoxyphenyl)piperazine), a novel PPAR ligand candidate, and investigated the underlying signaling path...
ppary中枢神经系统损伤治疗的新作者:单位:邮编:关键词过氧化物酶增殖物激活受体y;中枢神经系统损伤;神经保护过氧化物酶体增殖物激活受体yppary是一类由配体激活的核转 录因子,为核受体超家族中的成员之一。1990年isseman等首次
- 《Journal of Ethnopharmacology An Interdisciplinary Journal Devoted to Bioscientific Research on Indigenous Drugs》 被引量: 0发表: 2021年 Pioglitazone prevents cardiac remodeling in high-fat, high-calorie-induced Type 2 diabetes mellitus. The agonists of peroxisome proliferator-activated receptor-gamma ...
In male ZDF rats, fenofibrate and other PPARα agonists have only a minor effect and part of the reported effects of PPARα agonists on glucose control in male ZDF rats could be related to decreased food intake, which is typical for these drugs in male ZDF rats[21]. PPARγ agonist ...
At present, there are barely drugs in the market. In summary, we processed pahrmacophore virtual screening, docking analysis (CDOCKER), ADMET prediction, and molecular dynamics simulation (MDs) to screen the CHEMBL database to find potential dual PPARα/γ agonists in our work. Firstly, we ...
4.7 PPAR-gamma agonists (PPAR-γ) Peroxisome proliferator-activated nuclear receptorγ (PPARγ) is a ligand-activated transcription factor regulating lipid metabolism and inflammation (Landreth, 2007). Agonists such as thiazolidinediones (TZDs) have been approved for use in T2DM since 1997, functioning...
molecular docking and ADME predictions were carried out using soft ware Schrodinger Suite 2009.Results: It was observed by molecular dynamics simulations that these novel agonists not only possessed the same function as GW409544 did in activating PPAR-alpha and PPAR-gamma, but also had more ...
Alkoxy indole-3-acetic acid derivative acting as ppar α/γ/δ agonists, preparation method thereof, and pharmaceutical composition containing same as active ingredient The present invention relates to an alkoxy indole-3-acetic acid derivative, a preparation method thereof, and a pharmaceutical compositi...
INT131 (also known as CHS-131) is a novel, first-in-class, selective modulator of peroxisome proliferator-activated receptor gamma (PPARγ). The PPARγ is a transcription factor belonging to the steroid/thyroid/retinoid receptor superfamily. To date, PPARγ agonists have been therapeutic agents ...