Chen, Agonist-PPAR g interactions: molecular modeling study with docking approach, International Journal of Quantum Chemistry 93 (2003) 405e410.Xiao Ying Xu,,Feng Cheng,Jian Hua Shen,Hua Liang Jiang et al.Agonist-PPARγ interactions : Molecular modeling study with docking approach. International ...
The mechanism of action of the PPARs Peroxisome proliferator-activated receptors (PPARs) are nuclear receptors and have been initially described as molecular targets for compounds which induce... J Berger,DE Moller 被引量: 196发表: 2005年 β-Aminoisobutyric Acid Prevents Diet-induced Obesity in ...
Antidepressant-like effects of rosiglitazone, a PPARgamma agonist, in the rat forced swim and mouse tail suspension tests. Behav Pharmacol 2009; 20: 635–642. 37 Sadaghiani MS, Javadi-Paydar M, Gharedaghi MH, Fard YY, Dehpour AR. Antidepressant-like effect of pioglitazone in the forced ...
PPARγ activation with pioglitazone also induces profound multilocularization in adipocytes of adult WAT To further support the mechanism of adipocyte mul- tilocularization by PPARγ activation, we treated the mice with another thiazolidinedione-derived selec- tive PPARγ agonist, pioglitazone (∼15 ...
Interestingly, the potential mechanism responsible for the regulation of inflammatory and immunologic processes of PPAR-γ is independent of the direct transcriptional activity of the receptor, whereas involving in repression of the signaling pathways such as mitogen-activated protein kinase (MAPK) and ...
The PPARgamma agonist activity had been investigated and its exerted benefits are inhibition of inflammation in methylglyoxal (MG)-treated rats, prevention of pancreas impairment causing advanced glycation endproducts (AGEs), promotion of insulin expressionin vivoandin vitro, and attenuated carboxymethyl...
2.4. Structure-Based Drug Designing The concept of structure-based drug designing was implemented for known com- pounds and drug-targeting proteins [25]. The ligand binding domain region of Peroxisome Proliferator-activated Receptor PPAR gamma amino acids such as Phe282, Cys285, Gln286, Molecules ...
Agonist binding unmasks lysine 358 in the LBD for SUMOylation, hence conferring repressive activity to PPARα [22]. Table 1. Functional analysis of PPARα structural domains. PPARα displays a classical NR canonical architecture. PPARα domains (from A to F) fulfil distinct functions by ...
In gliomas, the canonical Wingless/Int (WNT)/β-catenin pathway is increased while peroxisome proliferator-activated receptor gamma (PPAR-γ) is do
In addition, selective modulators of PPARγ have a more dynamic effect on the conformation of AF-2 than TZD full agonists19, this conformational change also results in differential cofactors profiling20. Conclusively, transactivity is not the direct mechanism underlying the PPARγ antidiabetic ...