Agonist binding unmasks lysine 358 in the LBD for SUMOylation, hence conferring repressive activity to PPARα [22]. Table 1. Functional analysis of PPARα structural domains. PPARα displays a classical NR canonical architecture. PPARα domains (from A to F) fulfil distinct functions by ...
Antidepressant-like effects of rosiglitazone, a PPARgamma agonist, in the rat forced swim and mouse tail suspension tests. Behav Pharmacol 2009; 20: 635–642. 37 Sadaghiani MS, Javadi-Paydar M, Gharedaghi MH, Fard YY, Dehpour AR. Antidepressant-like effect of pioglitazone in the forced ...
PPARγ activation with pioglitazone also induces profound multilocularization in adipocytes of adult WAT To further support the mechanism of adipocyte mul- tilocularization by PPARγ activation, we treated the mice with another thiazolidinedione-derived selec- tive PPARγ agonist, pioglitazone (∼15 ...
Chen, Agonist-PPAR g interactions: molecular modeling study with docking approach, International Journal of Quantum Chemistry 93 (2003) 405e410.Xiao Ying Xu,,Feng Cheng,Jian Hua Shen,Hua Liang Jiang et al.Agonist-PPARγ interactions : Molecular modeling study with docking approach. International...
Interestingly, the potential mechanism responsible for the regulation of inflammatory and immunologic processes of PPAR-γ is independent of the direct transcriptional activity of the receptor, whereas involving in repression of the signaling pathways such as mitogen-activated protein kinase (MAPK) and ...
The PPARgamma agonist activity had been investigated and its exerted benefits are inhibition of inflammation in methylglyoxal (MG)-treated rats, prevention of pancreas impairment causing advanced glycation endproducts (AGEs), promotion of insulin expressionin vivoandin vitro, and attenuated carboxymethyl...
Peroxisome Proliferator-activated Receptor α (PPARα) Agonist Treatment Reverses PPARα Dysfunction and Abnormalities in Hepatic Lipid Metabolism in Ethan... Proper function of the peroxisome proliferator-activated receptor alpha (PPARalpha) is essential for the regulation of hepatic fatty acid metabolism...
Antidiabetic and hypolipidemic effects of a novel dual peroxisome proliferator-activated receptor (PPAR) alpha/gamma agonist, E3030, in db/db mice and beag... KasaiS,Inoue T,Yoshitomi H,et al.Antidiabetic and hypolipidemic effects of a novel dual peroxisome proliferator-activated receptor(PPAR)...
In addition, selective modulators of PPARγ have a more dynamic effect on the conformation of AF-2 than TZD full agonists19, this conformational change also results in differential cofactors profiling20. Conclusively, transactivity is not the direct mechanism underlying the PPARγ antidiabetic ...
Molecular mechanism of PPARα action and its impact on lipid metabolism, inflammation and fibrosis in non-alcoholic fatty liver disease J. Hepatol., 62 (2015), pp. 720-733 View PDFView articleView in ScopusGoogle Scholar Quinlan and Hall, 2010 A.R. Quinlan, I.M. Hall BEDTools: a flexibl...