Mutation Research/fundamental & Molecular Mechanisms of MutagenesisCorton JC, Lapinskas PJ, Gonzalez FJ: Central role of PPARalpha in the mechanism of action of hepatocarcinogenic peroxi- some proliferators. Mutat Res 2000, 448(2):139-151.
Peroxisome proliferator-activated receptor alpha is restricted to hepatic parenchymal cells, not Kupffer cells: implications for the mechanism of action of peroxisome proliferators in hepatocarcinogenesis Carcinogenesis, 21 (2000), pp. 823-826 View in ScopusGoogle Scholar [121] S. Rommelaere, V. Mille...
The mechanism of action of the PPARs Peroxisome proliferator-activated receptors (PPARs) are nuclear receptors and have been initially described as molecular targets for compounds which induce... J Berger,DE Moller 被引量: 196发表: 2005年 β-Aminoisobutyric Acid Prevents Diet-induced Obesity in ...
J. Role of PPAR alpha in the mechanism of action of the nongenotoxic carcinogen and peroxisome proliferator Wy-14,643. Carcinogenesis 18, 2029–2033 (1997). Article CAS PubMed Google Scholar Evans, R. M., Barish, G. D. & Wang, Y. X. PPARs and the complex journey to obesity. Nat...
Fibrates are widely used hypolipidemic drugs that regulate the expression of many genes involved in lipid metabolism by activating the peroxisome proliferator-activated receptor alpha (PPARalpha). The objective of this study was to investigate the mechanism of action of peroxisome proliferators and PPAR...
Next, we sought to study the mechanism of action of PAR5359, and the target cell type responsible for the superiority of dual agonism over single agonism. Our AI-guided approach predicted crypt top epithelium and macrophages as a site of action (Fig. 2f). Based on prior studies with single...
The Mechanism of Action of Clofibrate and Tetranicotinoylfructose (Bradilan) on the Kinetics of Plasma Free Fatty Acid and Triglyceride Transport in Type I... Abstract. The kinetics of plasma free fatty acid and triglyceride transport were assessed in 20 patients with idiopathic hypertriglyceridaem...
Molecular mechanism of PPARalpha action and its impact on lipid metabolism, inflammation and fibrosis in non- alcoholic fatty liver disease. J Hepatol 2015; 62: 720–733. 3 Foukas LC, Berenjeno IM, Gray A, Khwaja A, Vanhaesebroeck B. Activity of any class IA PI3K isoform can sustain ...
Corton JC, Lapinskas PJ, Gonzalez FJ: Central role of PPARalpha in the mechanism of action of hepatocarcinogenic peroxisome proliferators. Mutation research. 2000, 448 (2): 139-151. Article CAS PubMed Google Scholar Klaunig JE, Babich MA, Baetcke KP, Cook JC, Corton JC, David RM, De...
Transcriptional coregulators in the control of energy homeostasis. Trends Cell Biol. 17, 292–301 (2007). CAS PubMed Google Scholar Pawlak, M., Lefebvre, P. & Staels, B. Molecular mechanism of PPARα action and its impact on lipid metabolism, inflammation and fibrosis in non-alcoholic ...