PPAR‐alpha agonists as novel antiepileptic drugs: preclinical findings. PLos One. 2013;8(5):e64541.Puligheddu M, Pillolla G, Melis M, Lecca S, Marrosu F, De Montis MG, et al. Ppar-alpha agonists as novel antiepileptic drugs: preclinical findings. PLoS ONE 2013;8:e64541....
LSN862 is a novel peroxisome proliferator-activated receptor (PPAR)alpha/gamma dual agonist with a unique in vitro profile that shows improvements on gluco... Reifel-Miller,Anne,Otto,... - 《Molecular Endocrinology》 被引量: 291发表: 2005年 Comparative Gene Expression Profiles Induced by PPARγ...
Fibrates are widely used hypolipidemic drugs that regulate the expression of many genes involved in lipid metabolism by activating the peroxisome proliferator-activated receptor alpha (PPARalpha). The objective of this study was to investigate the mechanism of action of peroxisome proliferators and PPAR...
Structure of the PPARalpha and -gamma ligand binding domain in complex with AZ 242; ligand selectivity and agonist activation in the PPAR family Structure (2001) K.M. Darwish et al. Design, synthesis, and biological evaluation of novel thiazolidinediones as PPARgamma/FFAR1 dual agonists Eur. J...
L. et al. Fenofibrate (PPARalpha agonist) induces beige cell formation in subcutaneous white adipose tissue from diet-induced male obese mice. Mol. Cell. Endocrinol. 402, 86–94 (2015). CAS PubMed Google Scholar Zhou, L. et al. Coordination among lipid droplets, peroxisomes, and ...
USE OF A PPAR-ALPHA AGONIST AND METFORMIN FOR THE TREATMENT OF OBESITYThe present invention relates to the combined use of a PPARalpha agonist and metformin for decreasing serum triglycerides.doi:EP1569634 B1JUNIEN Jean-LouisEDGAR AlanCHAPUT Evelyne...
Fenofibrate, a peroxisome proliferator-activated receptor alpha agonist, improves hepatic microcirculatory patency and oxygen availability in a high-fat-di... Nonalcoholic fatty liver disease (NAFLD) is a common disease of chronic liver diseases. Peroxisome proliferator-activated receptor alpha (PPARalpha...
Structure-based design of indole propionic acids as novel PPARalpha/gamma co-agonists. In the quest for novel PPARα/γ co-agonists as putative drugs for the treatment of type 2 diabetes and dyslipidemia, we have used a structure-based design... B Kuhn,H Hilpert,J?rg Benz,... - 《Chem...
The expressed human PanK1α protein is biochemically active, its expression is stimulated by the PPARα agonist, bezafibrate (BF), and increased PanK1α activity resulted in elevated CoA levels. These data describe a mechanism for stimulation of CoA biosynthesis via increased PanK activity in human...
Synthesis, biological evaluation and molecular modeling investigation of chiral phenoxyacetic acid analogues with PPARalpha and PPARgamma agonist activity. ChemMedChem 2007, 2, 641–654. [Google Scholar] [CrossRef] Pisani, L.; Catto, M.; De Palma, A.; Farina, R.; Cellamare, S.; Altomare, ...