Combination PPAR- gamma agonist and immunosuppressive drugs for the treatment of undesirable immune responsesA method for treating or preventing undesirable immune response, comprising administering concurrently with immunosuppressants such as cyclosporin, rosiglitazone or pioglitazone and PPAR- gamma agonist. ...
Peroxisome proliferator-activated receptor gamma (PPARɣ) agonists exert powerful anticancer effects by suppressing tumor growth. In this study, we developed PPZ023 (1-(2-(ethylthio)benzyl)-4-(2-methoxyphenyl)piperazine), a novel PPAR ligand candidate, and investigated the underlying signaling path...
PPAR-gamma agonist Azelaoyl PAF increases frataxin protein and mRNA expression: new implications for the Friedreich's ataxia therapy. Cerebellum. 2009; 8 :... D Marmolino,F Acquaviva,M Pinelli,... - 《Cerebellum》 被引量: 77发表: 2009年 Friedreich's Ataxia: Autosomal Recessive Disease Caused...
ppary中枢神经系统损伤治疗的新作者:单位:邮编:关键词过氧化物酶增殖物激活受体y;中枢神经系统损伤;神经保护过氧化物酶体增殖物激活受体yppary是一类由配体激活的核转 录因子,为核受体超家族中的成员之一。1990年isseman等首次
There remains an acute need for development of safe and effective drugs for the treatment of NASH. The current study evaluated the effects of saroglitazar, a PPAR-α/γ agonist in a preclinical model of NASH. It demonstrated a systemic effect of the drug with decreased weight gain, improved...
Aleglitazar, a new, potent, and balanced dual PPARalpha/gamma agonist for the treatment of type II diabetes Bioorg. Med. Chem. Lett. (2009) A. Bugge et al. PPAR agonists, - Could tissue targeting pave the way? Biochimie (2017) P. Cronet et al. Structure of the PPARalpha and -gamm...
Besides control of hypertension and metabolic factors in aging individuals, PPAR agonists can be used as therapeutic drugs for the treatment of age-related inflammatory disorders such as atherosclerosis and diabetes. However, the evidence for a therapeutic role of PPARs in kidney diseases is still ...
NOVEL PHENYLPROPIONIC ACID DERIVATIVES AS PEROXISOME PROLIFERATOR-ACTIVATED GAMMA RECEPTOR MODULATORS, METHOD OF THE SAME, AND PHARMACEUTICAL COMPOSITION COMPRISING THE SAME The present invention provides a novel phenylpropionic acid derivative and a PPAR-γ modulator comprising the same as an active ...
Conclusion: Nebulized PPARγ agonist administration promotes lung maturation and prevents neonatal hyperoxia- induced lung injury in both males and females. Despite several technological and therapeutic advances over the last two or three decades, bronchopulmonary dyspla- sia remains a significant cause of...
INT131 (also known as CHS-131) is a novel, first-in-class, selective modulator of peroxisome proliferator-activated receptor gamma (PPARγ). The PPARγ is a transcription factor belonging to the steroid/thyroid/retinoid receptor superfamily. To date, PPARγ agonists have been therapeutic agents ...