As well, it has been revealed that PPAR-gamma and its agonists can regulate autophagy in different normal or cancer cells. However, their effects on autophagy modulation in obesity have been investigated in the limited number of studies. In the current comprehensive mechanistic review, we aimed ...
Synthetic and natural Peroxisome Proliferator-Activated Receptor (PPAR) agonists as candidates for the therapy of the metabolic syndrome[J]. Expert Opin Ther Targets,2017,21(3):333-348. [31] Hong F, Xu P,Zhai Y. The Opportunities and Challenges of Peroxisome Proliferator-Activated Receptors ...
4. Boileau C, Martel-Pelletier J, Fahmi H, Mineau F, Boily M, Pelletier JP. The peroxisome proliferator-activated receptor gamma agonist pioglitazone reduces the development of cartilage lesions in an experimental dog mode...
PPAR-gamma agonists as regulators of microglial activation and brain inflammation. and Minghetti, L. (2006). PPAR-γ agonists as regulators of microglial activation and brain inflammation. Curr. Pharm. Des. 12, 93-109... L Minghetti,A Bernardo - 《Current Pharmaceutical Design》 被引量: 313发...
Introduction: Selective agonists of the nuclear transcription factor peroxisome proliferator-activated receptor-gamma (PPAR-γ) are used for the treatment of type 2 diabetes. We reviewed their efficacy and safety for the treatment of major depression and the association of their potential antidepressant ...
Peroxisome proliferator-activated receptor gamma (PPARγ) is a nuclear receptor transcription factor that regulates cell growth and differentiation. In this study we analyzed the influence of PPARγ agonists on neural stem cell growth and differentiation in culture. We found that in vitro culture of ...
This effect was specific for PPARgamma agonists and was not seen with PPARalpha agonists. It was rapidly induced (within 4 h) and maintained throughout the observation period of 48 h. It was also concentration dependent (EC50 approximately 50 nM) and not inhibited by cycloheximide, suggesting ...
Rosiglitazone, 5-ASA or structurally analogous Compounds according to the general formula (I): or Compounds according to the general formula (Ia): For the induction of CAMP expression in tissues having PPAR-gamma receptors. Such tissues include epithelia or mucosae tissue having PPAR-gamma receptors...
Mice lacking adiponectin show decreased hepatic insulin sensitivity and reduced responsiveness to peroxisome proliferator-activated receptor gamma agonists. J Biolol Chem. 2006;281:2654–60. Article CAS Google Scholar Wallberg-Henriksson H, Zierath JR. GLUT4: a key player regulating glucose homeost...
Novel PPARgamma agonists GI 262570, GW 7845, GW 1929, and pioglitazone decrease calcium channel function and myogenic tone in rat mesenteric arteries. Pharmacology. 2005;73:15-22.Heppner TJ,Bonev AD,Eckman DM,et al.Novel PPARgamma agonists GI 262570, GW 7845, GW 1929, and pioglitazone ...