Thiazolidinediones-PPAR-γ Agonists; for the treatment of Type II Diabetes MellitusRekha S.Chandrashekhara S.Bhat, Vijeth NageshHaritas, AdhokshajaDheerathi T.Shivani, KalidasJournal of Advanced Zoology
This effect was specific for PPARgamma agonists and was not seen with PPARalpha agonists. It was rapidly induced (within 4 h) and maintained throughout the observation period of 48 h. It was also concentration dependent (EC50 approximately 50 nM) and not inhibited by cycloheximide, suggesting ...
Peroxisome Proliferation-Activated Receptor (PPAR)γ Is Not Necessary for Synthetic PPARγ Agonist Inhibition of Inducible Nitric-Oxide Synthase and Nitric... Peroxisome proliferation-activated receptor (PPAR)gamma agonists inhibit inducible nitric-oxide synthase (iNOS), tumor necrosis factor-alpha, and in...
Thiazolidinediones 主要是作用機制在所謂 peroxisome proliferator-activated receptor gamma (PPAR- γ)的接受器結合。PPAR- γ是細胞核內PPAR 的㆒種接受 器;PPARs 含有㆒接合子結合區(ligand-binding domain ) 與㆒ DNA 結合區 ( DNA-binding domain) 。PPAR- γ與另㆒核內接受器 retinoid acid X ...
Thiazolidinediones are peroxisome proliferator-activated receptor (PPAR)-gamma agonists that have been commonly used in the treatment of type 2 diabetes. They have also been considered for use in individuals with metabolic syndrome as they target a number of components of the syndrome through their mu...
The thiazolidinedione PPARγ agonists act in part through inhibition of the Wnt signaling pathway, showing there is a relationship between PPARγ and Wnt signaling. 展开 关键词: Keywords PPAR[gamma Wnt signaling osteoblasts cell proliferation
thiazolidinediones Dictionary Acronyms Related to thiazolidinediones:Biguanides,meglitinides A class of drugs used to combatINSULIN RESISTANCEin patients with Type 2DIABETES. These drugs are insulin sensitizing agents and act by binding selectively to preoxisome-proliferator-activated gamma receptors (PPAR)...
TZDs, PPAR γ agonists, could exhibit anti-inflammatory properties49, 50 and increase NO release from endothlial cells51, which may produce vasodilatation and attenuate vascular damage. Moreover, pioglitazone treatment could increase the number and function of endothelial progenitor cells (EPCs). ...
PPAR: a new pharmacological target for neuroprotection in stroke and neurodegenerative diseases. activators as well as thiazolidinediones and other non-thiazolidinedione PPARgamma agonists have been demonstrated to induce both preventive and acute ... R Bordet,T Ouk,O Petrault,... - 《Biochem Soc Tr...
The source of adipocytes is an important factor in determining the action of TZDs in vitro, and particular attention should be paid when evaluating the effect of PPAR- agonists on adipose tissues. 展开 关键词: Thiazolidinediones TZD PPAR-<IMG alt=[gamma] src="http://onlinelibrarystatic.wiley....