Analysis results of early placental PPAR signaling pathway gene expression from 8 women demonstrated 34 genes with a significant change in expression between IVF-ET and control group, 25 up-regulated; 9 down-regulated. KEGG pathway analysis indicated that IVF-ET manipulation extensively over-activated...
使用Cuffdiff软件识别样品中的差异基因,在保留具有统计学显著性意义(P<0.05)基因的基础上保留Fold change大于1.500 0或者小于0.667 0的基因[log2(1.500 0)=0.584 9,log2(0.667 0)=-0.584 9],对筛选出的差异基因用在线IGV软件进行GO...
regulated. GO analysis demonstrated that the positive regulation of interferon γ secretion, T cell receptor complex and C-X-C chemokine receptor activity were significantly enriched in the AI lesions. KEGG analysis demonstrated that the signaling pathways associated with primary immuno‐deficiency, PPAR...
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3D). Furthermore, PPAR pathway information generated by KEGG showed that FABP4 was an upstream gene of PPAR signaling pathway (Fig. S1). Meanwhile, numerous studies have shown that FABP4 positively regulates PPARγ signaling [20,21,22], which plays an important role in lipid metabolism [23,...
KEGG enrichment analysis showed that peroxisome proliferators-activated receptors (PPAR) signaling pathway might be vital toxic mechanism of Hg in the kidney. Then, our data showed that PPARγ agonist (GW 1929) attenuated HgCl 2 (15μg/ml)-induced apoptosis and NLRP3 inflammasome activation via ...
(4)KEGG通路分析发现:目标基因会因RRE激活PPARα通路而得到进一步的调控。同时,RRE的摄入可通过调控HMGCR和CYP7A1基因表达进而抑制肝脏胆固醇的合成和转化,并且通过下调LDLR抑制胆固醇的转运。此外,RRE处理可以加速甘油三酸酯向脂肪酸的转化。综上所述:本文揭示了RRE通过PPARα信号通路改善高脂饮食诱导的小鼠高脂血症。
Most importantly, by using Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analysis, we found that the expression of multiple genes and proteins was associated with PPARα, β/δ, and γ, which were altered in both the transcriptomics and proteomics profiles in the atrial tissue...
3A). For the selected differentially expressed mRNAs (545 + 85), KEGG pathways enrichment analysis revealed that the gene set was mainly involved in processes related to the PPAR signaling pathway and arachidonic acid metabolism (Fig. 3B). Furthermore, heat map analysis of the immune-...
KEGG pathway enrichment analysis among mice in the QYQC, DSS, and Ctrl groups (n = 3). C Volcano plot of differentially expressed genes between QYQC and DSS groups (n = 3). D GSEA of PPAR signaling pathway and TCA cycle between QYQC and DSS groups (n...