Recent studies that have supported the continuing physiologic and therapeutic relevance of the PPARgamma pathway also provide opportunities to develop newer classes of molecules that reduce or eliminate adverse effects. This review highlights key advances in understanding PPARgamma signaling in energy ...
PPAR-gamma signaling pathway in placental development and function: a potential therapeutic target in the treatment of gestational diseases. Theocharis, "PPAR-γ signaling pathway in placental development and function: a potential therapeutic target in the treatment of gestational diseases," Expert... ...
In this review, we focus on the chemo-preventive properties of monascin against metabolic syndrome through PPARgamma and Nrf2 pathways.doi:10.1039/c3fo60575bHsu, Wei-HsuanPan, Tzu-MingThe Royal Society of ChemistryFood & Function... WH Hsu,TM Pan - 《Food & Function》 被引量: 25发表: 20...
Recent studies have demonstrated that the endogenously produced peroxisome proliferator-activated receptor gamma (PPARγ) antagonist cyclic phosphatidic acid (cPA), which is structurally similar to LPA, inhibits cancer cell invasion and metastasis in vitro and in vivo. We recently observed that cPA ...
we generatedChd7conditional knockout mice and unveiled the essential role of CHD7 in MSC fate decisions by suppressing the peroxisome proliferator-activated receptor gamma (PPAR-γ) signaling pathway. Such findings might provide insight into the pivotal regulatory role of CHD7 in bone development and...
Cytosolic phospholipase A2alpha and peroxisome proliferator-activated receptor gamma signaling pathway counteracts transforming growth factor beta-mediated... Cytosolic phospholipase A2 α and peroxisome proliferator-activated receptor γ signaling pathway counteracts transforming growth factor β -mediated ...
Simvastatin activates the PPARgamma-dependent pathway to prevent left ventricular hypertrophy associated with inhibition of RhoA signaling. Tex Heart Inst J. 40, 140–147 (2013). PubMed PubMed Central Google Scholar Du, H. et al. Effects of peroxisome proliferator-activated receptor gamma in ...
Peroxisome proliferator–activated receptor gamma (PPARγ), a lipid-activated transcription factor, has been implicated in differentiation and lipid metabolism of various cell types. Here, we show that PPARγ is differentially expressed in normal and pathological human sebocytes and appears to have ...
Arctigenin promotes bone formation involving PI3K/Akt/PPAR gamma signaling pathway This study investigated the mechanisms through which arctigenin promotes osteogenesis. Bone marrow mesenchymal stem cells (BMSCs) from ovariectomized (OVX)... XTZ Li - 《Chemical Biology & Drug Design》 被引量: 0发表:...
(PPARγ)caninhibittheinvasionandmetastasisofhepatocellularcarcinoma(HCC)byinhibitingprolifer ationandadhesionofHCCcells,degradationofextracellularmatrixandangiogenesis.Therefore,themecha nismsthatPPARγsignalingpathwayinhibitstheinvasionandmetastasisofHCCmayprovidehelpfortheclini caltreatment,andisexpectedtoimprovethe...