PPAR-γ blocks the pro-inflammatory action of IFN-γ by inhibiting the JAK-STAT pathway. Relationship with disease Due to the breadth and complexity of the PPAR signaling pathway, this pathway is known to be associated with many diseases, including the following: Liver cancer Hepatocellular ...
PPAR signaling pathway is a key modulator of liver proteome in pups born to vitamin B(12) deficient rats. A., Basak, T., Bhardwaj, G. et al., PPAR signaling pathway is a key modulator of liver proteome in pups born to vitamin B(12) deficient rats. ... S Ahmad,KA Kumar,T Basak...
Mechanism study of liver steatosis induced by amiodarone via PPARαsignaling pathway 在线阅读 免费下载 引用 收藏 分享 摘要 目的探讨胺碘酮诱导的肝脏脂肪变的机制。方法8周雄性C57BL/6J小鼠分为3组,每组5只:正常饮食为空白对照组(WT组,n=5);胺碘酮(150 mg·kg-1·d-1)灌胃10...展开更多 Objective To...
proliferator-activated receptor (PPAR) signaling pathway, including a scavenger receptor (CD36), adipocyte fatty acid binding protein 4 (FABP4), enoyl-CoA hydratase (EHHADH), acetyl-CoA acyltransferase 1 (ACAA1), and phosphoenolpyruvate carboxykinase (PEPCK) in DBDCT-treated Rat Liver (BRL) cells...
Cytosolic Phospholipase A2α and PPAR-γ Signaling Pathway Counteracts TGF-β-mediated Inhibition of Primary and Transformed Hepatocyte Growth Hepatocellular carcinoma often develops in the setting of abnormal hepatocyte growth associated with chronic hepatitis and liver cirrhosis. Transforming gr... H ...
Objective To investigate the effects of Shenling Baizhu San on hepatic lipid metabolism in mice with metabolic associated fatty liver disease (MAFLD) based on the KLF16/PPAR-α signaling pathway. Methods C57 BL/6 mice were randomly divided into normal group, model group and Shenling Baizhu San ...
(P <0.001)and increased the expressions of PPAR α,CYP7A1,and CPT-1in the liver of HLP rats (P <0.001).Conclusion Yacon root extract can reduce serum TG and TC levels in HLP rats possibly by inhibiting HMGCR expression and activating the PPAR α/CYP7A1/CPT-1signaling pathway,thereby ...
(PPARγ)caninhibittheinvasionandmetastasisofhepatocellularcarcinoma(HCC)byinhibitingprolifer ationandadhesionofHCCcells,degradationofextracellularmatrixandangiogenesis.Therefore,themecha nismsthatPPARγsignalingpathwayinhibitstheinvasionandmetastasisofHCCmayprovidehelpfortheclini caltreatment,andisexpectedtoimprovethe...
急性肝衰竭(acute liver failure,ALF)是指突然出现大量肝细胞坏死或肝功能显著异常的一种综合征,常由病毒性肝炎,摄入药物或有毒物质[1],肝脏缺血再灌注等引起。ALF 的预后极差,除了肝移植外,目前还没有有效的治疗方法[2]。虽然 ALF ...
Resveratrol protects against nonalcoholic fatty liver disease by improving lipid metabolism and redox homeostasis via the PPARα pathway. 白藜芦醇通过 ppar α 途径改善脂质代谢和氧化还原稳态,对非酒精性脂肪性肝病具有保护作用。影响因子:3.10DOI:10.1139/apnm-2019-0057...