et al. PPAR-γ dependent and independent effects on macrophage-gene expression in lipid metabolism and inflammation. Nat. Med. 7, 48–52 (2001). Article CAS PubMed Google Scholar Hevener, A.L. et al. Macrophage PPARγ is required for normal skeletal muscle and hepatic insulin sensitivity ...
The expression level of PPARα and its signaling pathway-related genes are disordered, which may cause a decrease in the transcription level of a series of genes involved in lipid metabolism, which leads to a decrease in fatty acid oxidation and a disorder in lipoprotein anabolism, resulting in...
Molecular Actions of PPARα in Lipid Metabolism and Inflammation[J]. Endocrine Reviews,2018,39(5):760-802. [4] Montaigne D, Butruille L,Staels B. PPAR control of metabolism and cardiovascular functions[J]. Nat Rev Cardiol,2021,18(12):809-823. [5] Christofides A,Konstantinidou E,Jani ...
Key words:Hidradenitis suppurativa,Peroxisome proliferator-activated receptors,High-throughput nucleotide sequencing,PPARα,PPARγ,Lipid metabolism 引用本文 何艳艳 马骁 惠云 王雯竹 王宝玺 曾荣 徐浩翔. 基于高通量测序对反常性痤疮中PPAR通路作用的初步探讨[J]. 中华皮肤科杂志, 2024,57(4):309-315. doi:10....
A previous enrichment analysis also revealed the importance of the PPAR signaling pathway in first trimester placenta, along with its link to lipid metabolism and other complex biological functions [26]. To corroborate these results, we stained sections of first trimester and term placentas with Oil...
.Conclusion Yacon root extract can reduce serum TG and TC levels in HLP rats possibly by inhibiting HMGCR expression and activating the PPAR α/CYP7A1/CPT-1signaling pathway,thereby promoting fatty acid βoxidation and bile acid metabolism.Keywords:yacon root extract;hyperlipidemia;lipid metabolism;...
Objective:To study the correlation of HIFs/PPAR signaling pathway activation degree and lipid metabolism in liver tissue of alcoholic fatty liver rat model.Methods:Adult SD rats were selected and alcoholic fatty liver rat models were est... LY Guo,YM Li,QC Li - 海南医科大学学报(英文版) 被引...
Differentially expressed proteins were involved mainly in lipid, protein and sugar metabolism. Interestingly, in Group B, several downregulated proteins (FABP1, FABP2, APOC3, HMGCS2, ACADM and PEPCK) were implicated directly in the peroxisome proliferator-activated receptor (PPAR) signaling pathway. ...
BACKGROUND: Irisin is released from fibronectin type III domain containing 5 (FNDC5) after hydrolysis and modification. In addition to regulating the main physiological functions of glucolipid metabolism, irisin also has the ability to regulate the proliferation and apoptosis of a variety of ...
2(TPM + 1)≤7), with lipid metabolism and PPAR pathways being commonly activated in both RXRA and PPARG alterations (Fig. 1d, Supplementary Fig. 4). Interestingly, cancer immunity-related cytokine and antigen processing/presentation pathways were commonly downregulated in MIBC bearing RXRA...