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et al. PPAR signaling pathway may be an important predictor of breast cancer response to neoadjuvant chemotherapy. Cancer Chemother Pharmacol 70, 637-644, doi: 10.1007/s00280-012-1949-0 (2012).Chen, Y. Z.; Xue, J. Y.; Chen, C. M.; Yang, B. L.; Xu, Q. H.; Wu, F.; Liu,...
A previous enrichment analysis also revealed the importance of the PPAR signaling pathway in first trimester placenta, along with its link to lipid metabolism and other complex biological functions [26]. To corroborate these results, we stained sections of first trimester and term placentas with Oil...
PPAR signaling pathway may be an important predictor of breast cancer response to neoadjuvant chemotherapy. PPAR signaling pathway may be an important predictor of breast cancer response to neoadjuvant chemotherapy[J]. Cancer Chemother Pharmacol, 2012, 70(5): ... YZ Chen,JY Xue,CM Chen,... -...
Cytosolic Phospholipase A2α and PPAR-γ Signaling Pathway Counteracts TGF-β-mediated Inhibition of Primary and Transformed Hepatocyte Growth Hepatocellular carcinoma often develops in the setting of abnormal hepatocyte growth associated with chronic hepatitis and liver cirrhosis. Transforming gr... H ...
Mechanistically, ACSM5 inhibited lipid accumulation of LF cells by inhibiting FABP4-mediated PPARγ signaling pathway, thereby improving hypertrophy and fibrosis of LF. Conclusions our findings elucidated the important role of ACSM5 in the regulation of LF lipid accumulation and provide insight into ...
We recently observed that cPA negatively regulates PPARγ function by stabilizing the binding of the co-repressor protein, a silencing mediator of retinoic acid, and the thyroid hormone receptor. We also showed that cPA prevents neointima formation, adipocyte differentiation, lipid accumulation, and up...
While the effect of the APL fusion proteins on RARα signaling in hematopoiesis has been extensively studied, effects on signaling through other nuclear receptors remain largely uncharacterized. The peroxisome proliferator activated receptor (PPAR)-γ is a member of the nuclear receptor superfamily, ...
PPARs and TLR-NF-κB signaling pathway,respectively,has been broken down,resulting in inflammatory cascade and eventually causing chronic non-infectious inflammatory diseases,such as atherosclerosis,ulcerative colitis and rheumatoid arthritis.This review mainly focuses on the interaction between PPARs and ...
Signaling pathway(s) responsible for transforming growth factor β (TGFβ)-induced epithelial mesenchymal transition (EMT), invasion and migration of H460 cells (non-small cell lung cancer/ NSCLC ) was identified in the study. The results showed that TGFβ-induced p 38 /β-catenin/ PPARγ s...