工程技术2区)上发表了题为“Red raspberry extract (Rubus idaeus L shrub) intake ameliorates hyperlipidemia in HFD-induced mice through PPAR signaling pathway”的文章,文章对红树莓提取物(RRE)对高脂血症小鼠降血脂作用及其机制展开了系列研究。
表2分化不同时间PPAR信号通路的差异表达基因变化Table 2Changes of differentially expressed gene in PPAR signaling pathway at different differentiation time 3讨论 脂肪酸是机体主要能量来源之一,通过核受体如PPARs、肝脏X受体及各种转录因...
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Key words PPAR- ; signaling pathway; mechanism; disease Re cei ved : No vember 21 , 2 005 Ac cep ted : J anu ary 16, 20 06 Th is work was su ppor ted by the Nat ion al Natu ral Sci ence Fo unda tion of Chi na (No.302 7061 3), Key Fo unda tio n of Sh angh ai ...
Abstract:Objective To explore the role of the PPARα/HOXA10 signaling pathway in mediating the effect of adiponectin (APN) for improving endometrial receptivity in a rat model of polycystic ovary syndrome (PCOS). Methods Forty female SD rat models with letrozole-induced PCOS were randomized, with...
尿蛋白有显著改善。这些结果证实痹宁汤主要通过PPAR 信号通路在痛风肾疾病中发挥有效作用。结论:本研究初步预测了痹宁汤治疗痛风肾的主要有效成分、潜在靶点、信号通路,为进一步研究痹宁汤对痛风肾的保护机制及临床应用提供新的思路。 关键词 痹宁汤,网络药理学,转录组学,痛风肾 *通讯作者。
stress markers. Meanwhile, RT-qPCR and Western Blotting demonstrated that the mechanism of the antioxidant effect of EEP reversed the mRNA expression of EHHADH, HMGCR and SLC27A2 and the protein expression of FABP and HMGCR in AMPK and PPAR signaling pathways. This study integrates transcriptomics ...
Kupffer细胞在促进NAFLD中发挥了不同作用,产生IL-1b来抑制PPARα依赖的FA氧化导致脂质堆积;增加甘油三酯合成;产生TNF-a刺激甘油三酯储存,加重脂肪变性[15](图2)。有研究表明PPARβ/δ具有减轻化学诱导肝毒性[16]的作用,并提示PPARβ/δ在M2 Kupffer细胞中发挥作用,减少代谢综合征和T2DM[17](图2)。 3.3. 神经...
摘要: Purpose Neoadjuvant chemotherapy for advanced breast cancer may improve the radicality for a subset of patients, but others may suffer from severe adverse drug reactions without any benefit. To...关键词: Neoadjuvant Gene expression Chemotherapy response PPAR pathway DNA repair ...
2, 5-hexanedione downregulates nerve growth factor and induces neuron apoptosis in the spinal cord of rats via inhibition of the PI3K/Akt signaling pathway[J]. PLoS One, 2017, 12(6): e0179388. [40]Tian K, Wang YX, Li LX, et al. Neuronal death/apoptosis induced by intracellular Zinc ...