摘要: Purpose Neoadjuvant chemotherapy for advanced breast cancer may improve the radicality for a subset of patients, but others may suffer from severe adverse drug reactions without any benefit. To...关键词: Neoadjuvant Gene expression Chemotherapy response PPAR pathway DNA repair ...
Wu, et al., PPAR signaling path- way may be an important predictor of breast cancer response to neoadjuvant che- motherapy, Cancer Chemother. Pharmacol. 70 (2012) 637-644.Chen YZ, Xue JY, Chen CM, et al. PPAR signaling pathway may be an important predictor of breast cancer response to...
(PPARγ)caninhibittheinvasionandmetastasisofhepatocellularcarcinoma(HCC)byinhibitingprolifer ationandadhesionofHCCcells,degradationofextracellularmatrixandangiogenesis.Therefore,themecha nismsthatPPARγsignalingpathwayinhibitstheinvasionandmetastasisofHCCmayprovidehelpfortheclini caltreatment,andisexpectedtoimprovethe...
Kupffer细胞在促进NAFLD中发挥了不同作用,产生IL-1b来抑制PPARα依赖的FA氧化导致脂质堆积;增加甘油三酯合成;产生TNF-a刺激甘油三酯储存,加重脂肪变性[15](图2)。有研究表明PPARβ/δ具有减轻化学诱导肝毒性[16]的作用,并提示PPARβ/δ在M2 Kupffer细胞中发挥作用,减少代谢综合征和T2DM[17](图2)。 3.3.神经退行...
因为脂肪细胞和白细胞之间的相互协作使这两个系统在病原体入侵时能够协调能量储存以维持生存。先天性淋巴细胞、CD4 + T 细胞和自然杀伤细胞等促炎症免疫细胞被巨噬细胞招募到脂肪组织中参与免疫反应。在肥胖诱发炎症的过程中,巨噬细胞还...
现发现PPAR- 在炎症、动脉粥样硬化、胰岛素抵抗和糖代谢的调节、肿瘤和肥胖和中起到重要的调节作用 [1] 。启动子和目标基因进行结合作用的区域 [9] ;③铰链区 (hingedomain),作为DNA和配体结合的区域;④ C端的E/F域或激活功能-2(activationfunction-2)是配体结合区域(LBD),与配体形成二聚体。 PPAR- 及其他...
PPAR-gamma signaling pathway in placental development and function: a potential therapeutic target in the treatment of gestational diseases. Theocharis, "PPAR-γ signaling pathway in placental development and function: a potential therapeutic target in the treatment of gestational diseases," Expert... ...
(PPAR) signal pathway and cancer risk; however, the results of these studies were inconsistent, and the role of the PPAR signaling pathway in cancer remains unclear. Therefore, the aim of this study was to further investigate the association between the PPAR signaling pathway and breast cancer ...
Abstract:Objective To explore the role of the PPARα/HOXA10 signaling pathway in mediating the effect of adiponectin (APN) for improving endometrial receptivity in a rat model of polycystic ovary syndrome (PCOS). Methods Forty female SD rat models with letrozole-induced PCOS were randomized, with...
KEGG pathway analysis indicated that IVF-ET manipulation extensively over-activated PPAR signaling pathway. Immune tolerance, trophoblast invasion, syncytia formation, lipid and glucose metabolism, inflammatory response and other complex biological functions were disturbed. RT-qPCR results and proteins staining...