Novelty RSV improved lipid metabolism and redox homeostasis and oxidative stress in NAFLD via the PKA/AMPK/PPARα signaling pathway. RSV may have a greater beneficial effect in the early prevention of hepatic steatosis. 摘要 : 白藜芦醇 (RSV) 是一种著名的生物活性化合物,据报道可发挥广泛的健康...
ppary中枢神经系统损伤治疗的新作者:单位:邮编:关键词过氧化物酶增殖物激活受体y;中枢神经系统损伤;神经保护过氧化物酶体增殖物激活受体yppary是一类由配体激活的核转 录因子,为核受体超家族中的成员之一。1990年isseman等首次
PPARγmRNA分为4种亚型,由于启动子和剪切方式的不同,编码两种蛋白质,其中PPARγ1 mRNA、PPARγ3 mRNA、PPARγ4 mRNA翻译的蛋白相同,而PPARγ2 mRNA翻译的蛋白N末端比前者多30个氨基酸残基〔2〕。 PPARγ的配体可分为内源性和外源性配体两大类。外源性配体类型包括胰岛素增敏剂噻唑烷二酮类药物如匹格列酮、环...
These results indicated that pelargonidin exerts anti-adipogenic activity in 3T3-L1 cells through inhibition of PPAR-gamma signaling pathway, and pelargonidin could be used as a potential anti-obesity agent. 展开▼ 机译:Pelargonidin是一种天然化合物,其在水果中广泛存在,并施加抗氧化剂,抗动脉粥样...
(PPARγ)caninhibittheinvasionandmetastasisofhepatocellularcarcinoma(HCC)byinhibitingprolifer ationandadhesionofHCCcells,degradationofextracellularmatrixandangiogenesis.Therefore,themecha nismsthatPPARγsignalingpathwayinhibitstheinvasionandmetastasisofHCCmayprovidehelpfortheclini caltreatment,andisexpectedtoimprovethe...
(NFAT)signalingpathways.It foamcell andcell maintainshomeostasis byinhibiting differentiating,inflammation P13K, proliferation.Itglucose by leptin,adiponectin inhibitstumorcells cell is signalingpathway.It growthbymediatingcycles.Also,itclosely relatedto in obesity ofthose byparticipatingadipocytes differentiation....
机译:PPARα-FGF21激素轴通过肝脏JNK信号通路促进代谢调节 7. The PPARα-FGF21 Hormone Axis Contributes to Metabolic Regulation by the Hepatic JNK Signaling Pathway [O] . Vernia Santiago, Cavanagh-Kyros Julie, Garcia-Haro Luisa, 2014 机译:PPARα-FGF21激素轴通过肝脏JNK信号通路促进代谢调节 获取...
signaling pathway and reduce the inflammatory response in CIA rats. The therapeutic effect of SSD was significant with the increase of dose.Conclusion:SSD can relieve joint symptoms in CIA rats and alleviate inflammation by inhibiting the FABP4/PPARγ/NFκB signaling pathway. The effect of high-...
4) Signaling pathway 信号通路 1. Differences of signaling pathway of lung injury between C57BL/6 and C3H/He mice exposed to fine particle; 大气细颗粒物致C57BL/6和C3H/He品系小鼠肺损伤过程中信号通路的差异 2. Constitutive activation of JAK/STAT signaling pathway in leukemogenesis; 白血病形成...