and chemokine-chemokine receptor interaction were significantly enriched in the AI lesions. GSEA demonstrated that the PPAR signaling pathway was significantly weakened in the AI lesions. The mRNA expression levels of PPARA and PPARG were significantly lower in the AI patients (0.336 ± 0.120, 0.253 ...
10. Li Y, Yuan L, Jiang S, Liu S, Xia L, Shen H, et al. Interleukin-35 stimulates tumor necrosis factor-α activated osteoblasts differentiation through Wnt/β-catenin signaling pathway in rheumatoid arthritis. Int ...
OBJECTIVE: To investigate the role and mechanism of irisin/peroxisome proliferator-activated receptor alpha (PPAR伪) signaling pathway mediated heme oxygenase-1 in regulating the balance between proliferation and apoptosis of vascular smooth muscle cells. METHODS: FNDC5 overexpression and silencing ...
表2分化不同时间PPAR信号通路的差异表达基因变化Table 2Changes of differentially expressed gene in PPAR signaling pathway at different differentiation time 3讨论 脂肪酸是机体主要能量来源之一,通过核受体如PPARs、肝脏X受体及各种转录因...
Abstract:Objective To explore the role of the PPARα/HOXA10 signaling pathway in mediating the effect of adiponectin (APN) for improving endometrial receptivity in a rat model of polycystic ovary syndrome (PCOS). Methods Forty female SD rat models with letrozole-induced PCOS were randomized, with...
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篇名: 白术乙醇提取物调节PPAR-γ信号通路促进小胶质细胞摄取及降解Aβ的作用机制研究 TITLE: Study on the promotion effect mechanism of ethanol extract from Atractylodes macrocephala on microglia phagocytosis and degradation of Aβ based on regulating PPAR-γ signaling pathway 摘要: 目的 基于过氧化物酶...
It maintains glucose homeostasis by PI3K, leptin, adiponectin signaling pathway. It inhibits tumor cells growth by mediating cell cycles. Also, it is clos ely related to obesity by participating in adipocytes differentiation. Thorough understanding of those signaling pathways and interaction of relevant ...
This study reviews the research progress of this signaling pathway in thecardiovascular system,renal system,immune system and other systems in order to provide new targets and strate-gies for its treatment.Key words:PPAR -γ;AP -1;signaling pathway;diseases1 转录因子 PPAR -γ 概述过氧化物酶体...