Molecular Actions of PPARα in Lipid Metabolism and Inflammation[J]. Endocrine Reviews,2018,39(5):760-802. [4] Montaigne D, Butruille L,Staels B. PPAR control of metabolism and cardiovascular functions[J]. Nat Rev Cardiol,2021,18(12):809-823. [5] Christofides A,Konstantinidou E,Jani ...
Peroxisome proliferator-activated receptor gamma (PPAR γ) is a nuclear receptor, originally described in adipose tissue, that controls the expression of a large number of regulatory genes in lipid metabolism and insulin sensitization. Well known by endocrinologists, thiazolidinediones (TZDs) are ...
重组人过氧化物酶增殖物激活受体γ (LBD) (His-tagged)又称PPAR-gamma, Peroxisome Proliferator-activated Receptor γ Ligand Binding Domain, PPAR-gamma (LBD), NR1C3, PPARG (LBD).其对应NCBI基因号为5468.来源宿主 提供的【PPARG】重组人过氧化物酶增殖物激活受体γ (LBD) (His-tagged)蛋白产品来源为大肠...
The mechanisms by which PPAR gamma and adiponectin regulate glucose and lipid metabolism[J]. Nippon Yakurigaku Zasshi,2003,122(4):294 300. [13]Vidal Puig AJ, Considine RV, Jimenez Linan M, et al. Peroxisome proliferator activated receptor gene expression in human tissues. Effects of obesity,...
Molecular mechanism of PPARα action and its impact on lipid metabolism, inflammation and fibrosis in non-alcoholic fatty liver disease. J. Hepatol. 62, 720–733 (2015). CAS PubMed Google Scholar Oishi, Y. et al. Krüppel-like transcription factor KLF5 is a key regulator of adipocyte ...
In this review, novel mechanistic insights into PPARα action, in hepatic lipid metabolism, under different nutritional states, and its role in liver inflammation and fibrosis are presented. We also summarize the (pre)clinical findings on PPAR agonists under development for NAFLD treatment. Functional...
Metabolism Transcriptional regulatory elementsAbstract Cysteine dioxygenase 1 (Cdo1) is a key enzyme in taurine synthesis. Here we show that Cdo1 promotes lipolysis in adipose tissue. Adipose-specific knockout of Cdo1 in mice impairs energy expenditure, cold tolerance and lipolysis, exacerbates diet-...
Peroxisome proliferator-activated receptor-gamma (PPARγ) is a major modulator of cellular lipid metabolism and organelle differentiation. To understand whether autophagy is involved in the processes of dysregulated fatty acid oxidation and induced oxidative stress accompanying prostatic carcinogenesis, we char...
[关键词] 过氧化物酶体增殖物激活受体γ; 脂肪细胞分化; 肥胖; 糖脂代谢 [中图分类号] Q53;Q54 [文献标识码] A [文章编号] 1673 2588(2008)01 0014 05 RoleofPPARγinadipocytedifferentiationand glucoseandlipidmetabolism YANGZhi,LIUZhao Qian (InstituteofClinicalPharmacology,CentralSouthUniversity,Changsha410...
Until recently, the genes regulated by PPARs were those believed to be predominantly associated with lipid metabolism. Recently, an immunomodulatory role for PPAR gamma has been described in cells critical to the innate immune system, the monocyte/macrophage. In addition, evidence for an anti...