such as Akt signaling, during tumor progression30. Considering that Akt/mTOR pathway has been well established to play a central role in the regulation of cell lipid metabolism31,32, we hypothesized that MIEF2 overexpression may increase ROS production and thus activate ...
The Hedgehog (Hh) signaling pathway is highly conserved signaling pathway in cells. Steroids was found to play a vital role in Hh signaling pathway and aberrant Hh signaling was found to lead a series of disease correlate with abnormal lipid metabolism. This paper aimed to elucidate the ...
4.2.1 Lipid metabolism Lipid metabolism encompasses the processes of absorption, transport, synthesis, catabolism, and utilization of lipids by the body. Lipids serve as a vital source of energy for the body and are also a component of cell membranes, hormones, signaling molecules, and other esse...
Nature Metabolism volume 1, pages 1127–1140 (2019)Cite this article 2082 Accesses 20 Citations 31 Altmetric Metrics details Abstract Although mammalian target of rapamycin 1 (mTORC1) negatively regulates autophagy in cultured cells, how autophagy impacts mTORC1 signalling, in particular in an in ...
signaling pathways regulating pluripotency of stem cells); 3 pathways are related with immune system and inflammation (chemokine, Th17 cell differentiation and leukocyte migration); 2 related with the endocrine system (oxytocin and GnRH signaling pathway); 2 with lipid membrane metabolism (such as glyc...
Adipocytokines are signaling proteins that play key roles in the regulation of lipid and glucose metabolism, the neuroendocrine system, and the immune system, as well as energy homeostasis [151]. Adiponectin is also an anti-inflammatory adipokine that regulates the synthesis of FAs, glucose uptake,...
et al. Di-2-ethylhexyl phthalate (DEHP) induced lipid metabolism disorder in liver via activating the LXR/SREBP-1c/PPARα/γ and NF-κB signaling pathway. Food and Chemical Toxicology, 2022, 165: 113119. doi:10.1016/j.fct.2022.113119 17. Xue, Z., Zhuang, J., Bai, H. et al. VDR...
Targeting cell metabolism offers promising opportunities for the development of drugs to treat cancer. We previously found that the fatty acyl-CoA synthetase VL3 (ACSVL3) is elevated in malignant brain tumor tissues and involved in tumorigenesis. This st
The overexpression of miR-320 could inhibit the expression of AKIP1, which might induce the mitochondrial apoptotic pathway and influence glucose and lipid metabolism in cardiomyocytes in the case of ischemia-reperfusion (I/R) injury. Interestingly, in addition to the pathway described above, miR-...
S2F). To identify genes or signaling pathways that might bypass SBP-1 to regulate lipid metabolism, we performed a forward genetic screen for suppressors of the sbp-1(ep79) mutant. We treated the sbp-1(ep79) mutant with the mutagen, ethyl methanesulfonate, and monitored the growth rate and...