The Hedgehog (Hh) signaling pathway is highly conserved signaling pathway in cells. Steroids was found to play a vital role in Hh signaling pathway and aberrant Hh signaling was found to lead a series of disease correlate with abnormal lipid metabolism. This paper aimed to elucidate the ...
4.2.1 Lipid metabolism Lipid metabolism encompasses the processes of absorption, transport, synthesis, catabolism, and utilization of lipids by the body. Lipids serve as a vital source of energy for the body and are also a component of cell membranes, hormones, signaling molecules, and other esse...
such as Akt signaling, during tumor progression30. Considering that Akt/mTOR pathway has been well established to play a central role in the regulation of cell lipid metabolism31,32, we hypothesized that MIEF2 overexpression may increase ROS production and thus activate ...
CD36-mediated intracellular lipid accumulation activates the PPARβ signaling pathway, which regulates mitochondrial metabolism and further enhances the immunosuppressive function of Treg cells in tumor [8]. Therefore, targeting CD36 in Treg cells can be an effective approach to restore effective anti-...
Currently, it is unknown why in human SCs initiation of a signalling pathway resulting in altered lipid metabolism is delayed. Herein, we found two molecules regulated in a species-specific manner, Shh and Medag up-regulated only in mouse or human PNI respectively (Figs. 2 and 4b, p, Suppl...
The underlying mechanism of IgA vasculitis (IgAV) and IgA vasculitis with nephritis (IgAVN) remains unclear. Therefore, there are no accurate diagnostic methods. Lipid metabolism is related to many immune related diseases, so this study set out to explor
The results showed that there are eleven lipid metabolic pathways were found during the prevention of BS15 treatment in SNE chickens by RNA-Seq, including the peroxisome proliferator-activated receptor (PPAR) signaling pathway and arachidonic acid metabolism. BS15 notably facilitated the expressions of...
The overexpression of miR-320 could inhibit the expression of AKIP1, which might induce the mitochondrial apoptotic pathway and influence glucose and lipid metabolism in cardiomyocytes in the case of ischemia-reperfusion (I/R) injury. Interestingly, in addition to the pathway described above, miR-...
Nature Metabolism volume 1, pages 1127–1140 (2019)Cite this article 1979 Accesses 19 Citations 32 Altmetric Metrics details Abstract Although mammalian target of rapamycin 1 (mTORC1) negatively regulates autophagy in cultured cells, how autophagy impacts mTORC1 signalling, in particular in an in ...
Insulin signaling plays an important role in the regulation of FA metabolism, underscoring the close relation between lipid and glucose metabolism. Insulin affects DNL on multiple levels, via induction of lipogenic genes, activation of sterol-response-binding-protein-1c (SREBP-1c) and Akt-regulated...