the relationship between lipid metabolism in glia and Alzheimer’s disease pathology remains poorly understood. Through single-nucleus RNA sequencing of brain tissue in Alzheimer’s disease, we have identified a microglial
Understanding the interface between nanomaterials and lipoproteins is crucial for gaining insights into their impact on lipoprotein structure and lipid metabolism. Here, we use graphene oxide (GOs) nanosheets as a controlled carbon nanomaterial model to
No.MetaboliteVIPaFCbPcPdFDReMetabolic pathway 4th week 1 LysoPC(15:0) 4.15 0.74 1.21E−04 5.88E−04 1.75E−04 Lipid metabolism 2 LysoPC(17:0) 3.71 0.82 4.78E−03 3.57E−02 4.78E−03 Lipid metabolism 3 Chenodeoxycholic acid 3.51 1.99 3.58E−04 7.71E−04 3.88E...
Pathway analysis revealed that the metabolites are implicated in the down-regulation of necroptosis, amino acid metabolism, and regulation of lipid metabolism by PPAR-α, biogenic amine synthesis, fatty acid metabolism, and the mTOR signaling pathway. Cholesterol metabolism, DNA repair, methylation ...
Lipid metabolism abnormalities, closely related to psoriasis and MI, might be an intermediate factor along the pathway from psoriasis to MI. Two meta-analyses highlighted that LDL cholesterol, lipoprotein A, and apolipoprotein B levels were considerably higher in individuals with psoriasis than in contr...
Lipid Metabolism de novo Fatty acid synthesis: FAS ACC 6GPD -FAS involved in the condensation of acetyl-CoA, malonyl-CoA, and NADPH catalyzes de novo fatty acid synthesis . -ACC is the first rate limiting enzyme in thede novolipogenesis process....
The evidence we provide indicates that the levels of calcium and phosphorus in the diet alter body fat content and lipid metabolism by modulating the response of the gut-liver axis to lipids. These effects are closely associated with the activation of the CAMKK2/AMPK signaling pathway.Introduction...
s t-test and fold change.FEnrichment pathway analysis of metabolomics data. The biochemical pathways were evaluated using p-value and enrichment ratio.GAge-related changes of metabolites belong to the pathways: purine catabolism (xanthine, uric acid) and analytes of creatine/arginine metabolism (...
Shackelford DB, Shaw RJ: The LKB1-AMPK pathway: metabolism and growth control in tumour suppression. Nature Rev. 2009, 9 (8): 563-575. CAS Google Scholar Levine AJ, Puzio-Kuter AM: The control of the metabolic switch in cancers by oncogenes and tumor suppressor genes. Science. 2010, ...
Indeed, it provides metabolic profiles that represent an integrated view of metabolism because it allows a sensitive detection of molecular changes over time, resulting from the interaction between intrinsic and extrinsic factors23. Metabolites, used as single targets or in combination within a ...