Pathways involved in lipid-induced insulin resistance in obesity - Watt, Steinberg - 2007 () Citation Context ...eatment (Figure 1D). Moreover, elevated basal lipolytic capacity of adipocytes is known to contribute to increased plasma FFA levels in human obesity (Boden and Shulman, 2002; ...
To assess the impact of lipid transfer on the recipient cells, we compared the transcriptomes of Caco-2 cells exposed to either BTWT or SLMUT cells in a transwell system. Genes involved in SL metabolism were differentially regulated over an 8-hour period depending on the treatment (targeted an...
In mammals, the white adipocyte is a cell type that is specialized for storage of energy (in the form of triacylglycerols) and for energy mobilization (as fatty acids). White adipocyte metabolism confers an essential role to adipose tissue in whole-body
This Educational Session aims to guide discussion on the heterogeneous cells and metabolism in the tumor microenvironment. It is now clear that the diversity of cells in tumors each require distinct metabolic programs to survive and proliferate. Tumors, however, are genetically programmed for high rate...
miRNAs present in OF- and UF-EVs, have the potential to regulate the expression of key genes involved in lipid metabolism in bovine embryos. In a previous study, Leal et al. [21], observed that when cultured with OF- and UF-EVs, the genesLDLR,FASN,PNPLA2, andPLIN2were down-regulated...
Disruptions in lipid metabolism have now been linked to several major health issues, including: Alzheimer's disease and other neurodegenerative conditions Type 2 diabetes and obesity Cancer Certain infectious diseases What's driving this research forward is lipidomics—the science of identifying and study...
Gene ontology analysis revealed that genes involved in nucleic acid metabolism processes were downregulated in neutron-irradiated mice, whereas genes involved in lipid metabolism were upregulated in x-ray irradiated animals. Cell cycle processes were significant among down-regulated genes at day 1, but...
In the next sections we will describe the function of two important metabolic regulators, mTOR and AMPK in T cell differentiation. We will also describe how the modulation of lipid metabolism can be used as a strategy for modulation of T cell differentiation. 7.1. Regulation of T cell ...
2. Molecular pathways associated with oxidative stress in diabetes mellitus The molecular pathways which have been noted to contribute to oxidative stress in diabetes are either involved with glucose metabolism or lipid metabolism. These cellular pathways are discussed below. 2.1. Glucose oxidation pathway...
The TME also induces the enhancement of fatty acid biosynthesis, uptake, storage, and oxidation of TAMs through mechanisms that are not yet fully understood.29This metabolic characteristic is associated with the functional transition of TAMs. The enhancement of lipid metabolism in TAMs not only suppor...