lipidmetabolismsignaling pathway.Background We assessed the effects of vitamin D supplementation on the associated molecular mechanisms that are involved in insulin and lipid metabolism of diabetic hemodialysis (HD). Methods A double-blind, randomized, placebo-controlled clinical trial was carried out in...
Metabolism of red-cell lipids. III. Pathways for phospholipid renewal 1. 1. Experiments on the conversion of various phospholipid precursors by red-cell ghosts indicated that monoacyl phosphoglycerides are the major acyl acceptors involved in the fatty acid incorporation into lipids of mature ...
To assess the impact of lipid transfer on the recipient cells, we compared the transcriptomes of Caco-2 cells exposed to either BTWT or SLMUT cells in a transwell system. Genes involved in SL metabolism were differentially regulated over an 8-hour period depending on the treatment (targeted an...
In mammals, the white adipocyte is a cell type that is specialized for storage of energy (in the form of triacylglycerols) and for energy mobilization (as fatty acids). White adipocyte metabolism confers an essential role to adipose tissue in whole-body
Gene ontology analysis revealed that genes involved in nucleic acid metabolism processes were downregulated in neutron-irradiated mice, whereas genes involved in lipid metabolism were upregulated in x-ray irradiated animals. Cell cycle processes were significant among down-regulated genes at day 1, but...
2. Molecular pathways associated with oxidative stress in diabetes mellitus The molecular pathways which have been noted to contribute to oxidative stress in diabetes are either involved with glucose metabolism or lipid metabolism. These cellular pathways are discussed below. 2.1. Glucose oxidation pathway...
Less NK cells in obese people; also produce less IFN gamma RNASeq on NOD mice; granzymes and perforins at top of list of obese downregulated Upregulated genes that were upregulated involved in lipid metabolism All were PPAR target genes ...
[79] and soybean oil can regulate lipid metabolism and directly improve renal function [80]. Glp-1 RA inhibits NHE3-dependent sodium reabsorption in the proximal tubule and has a direct renal protective effect on the renin-angiotensin system, which can improve inflammation, ischemia/hypoxia, ...
Finally, we summarize therapeutic strategies in which targeting lipid pathways can improve tumor response to chemo- or immunotherapy. Targeting lipid metabolism to slow down metastatic disease Metastases for all solid tumors account for 66.7% of cancer deaths [14], and their formation is a multistep...
in glucose, lipid, and amino acid metabolism.6,7In addition to the well-known phenomenon of aerobic glycolysis, cancer-specific metabolic changes have been discovered, including elevated lactate production, increased glutamine metabolism, fatty acid synthesis, and decreased fatty acid oxidation.1,2The...