3.2.3Glycerophospholipid metabolic pathway Glycerophospholipid metabolism is known to stimulate inflammation occurrence. Experimental analysis has shown that phosphatidylcholine (PC) and phosphatidylethanolamine
Among the 125 potential target genes, the GO analysis indicated that the down-regulated target genes in miRNA sample of the Han sheep were significantly overrepresented in 12 biological processes at p < 0.01 and a FDR < 0.05, of which the lipid metabolic process was the most significa...
We reconstructed significant parts of the SP metabolic pathway in iPAMs (Fig. 7). Ceramides, central molecules in the SP pathway, decreased in abundance in HNX-infected cells. EA infection enriched two types of ceramides, whereas Bartha K61 decreased the abundance of 1 type of ceramides. The ...
Pathway analysis suggested that down-regulation of these miRNAs could also result in higher insulin resistance, which is a significant risk factor for metabolic disease. Furthermore, we saw predicted targets of down-regulated miRNAs in the stable CAD to be involved in sphingolipid signalling. ...
Lipid metabolism changes occur in early Alzheimer's disease (AD) patients. Yet little is known about metabolic gene changes in early AD cortex. The lipid metabolic genes selected from two datasets (GSE39420 and GSE118553) were analyzed with enrichme
Bioinformatics and pathway analysis An important application of bioinformatics in metabolomics data mining is to facilitate pathway analysis [36,37]. Lipidomics, especially global/untargeted lipidomics, has the power to reveal a broad snapshot of metabolic events occurring in both closely and distantly...
Kyoto Encyclopedia of Genes and Genomes (KEGG) [22] has been the main source of information on metabolic pathways. However, KEGG lipid pathway representation is generally limited to generic lipid classes, i.e., including mainly the head-group information, and not including the fatty acid side-...
Lipid metabolites (n=113) from the merged dataset consisting of all HIV subjects (n=32) and controls (n=20) were inputted into MSEA and enrichment was assessed using the MSEA Metabolic Pathway library (n=88) and custom metabolite sets derived from Lipid Maps (n=5). Pathways were ...
Increasedde novofatty acid (FA) synthesis has been observed in many different types of cancer and is currently thought to be the major metabolic pathway exploited by cancer cells for FA acquisition36. To date, increased expressions of key regulators of lipogenesis, including SREBPs, acetyl-CoA ca...
Finally, we establish connections between structural changes in LDL and various lipid metabolic processes in macrophages, encompassing LDL uptake, lipid trafficking, accumulation, and efflux in macrophages, at both the molecular and cellular levels. Our findings demonstrate the important role of ...