Pathway analysis of metabolic geneslipid metabolismObjective:Hepatocellular carcinoma(HCC)is among the deadliest cancers in Thailand.The Thailand Initiative in Genomics and Expression Research for Liver Cancer(TIGER-LC)cohort was established to discover molecular markers that can be used for early detection...
Among the 125 potential target genes, the GO analysis indicated that the down-regulated target genes in miRNA sample of the Han sheep were significantly overrepresented in 12 biological processes at p < 0.01 and a FDR < 0.05, of which the lipid metabolic process was the most significa...
Moreover, Metabolic pathways of TG are not independent from the effects of the presence of structural lipids such as glycerophospholipids or sphingolipids, which may interact with TG metabolism at multiple levels [32]. PC is one of GPs and it has been reported to prevent TG accumulation and ...
again these associations persisted even after adjustment for clinical lipids (total cholesterol, HDL-cholesterol, triglycerides). Interestingly, we also observe associations of phosphatidylinositol species with SNPs in theLIPGregion, suggesting a larger metabolic effect of the ANGPTL3-LIPG pathway, at lea...
We reconstructed significant parts of the SP metabolic pathway in iPAMs (Fig. 7). Ceramides, central molecules in the SP pathway, decreased in abundance in HNX-infected cells. EA infection enriched two types of ceramides, whereas Bartha K61 decreased the abundance of 1 type of ceramides. The ...
Based on metabolic pathway analysis, we found that T1DCD mice displayed a higher level of lipid peroxidation in the brain than CONT mice. Lipids are essential ingredients in the cellular membrane that maintains normal structure and function of cells. Thus, excessive lipid oxidation destroys the ...
Serum samples were collected for metabolomic analysis during the development of the cachexia: at baseline, when the tumor was palpable, and when the mice demonstrated cachexia. The unsupervised statistical analysis demonstrated a distinct metabolic profile with the onset of cachexia. The critical ...
To delve deeper into these lipid metabolic alterations, the following section provides an in-depth analysis (Fig. 1). Fig. 1 Lipid metabolic reprogramming in cancer. Tumor cells enhance lipid metabolism by increasing exogenous lipid uptake and lipid synthesis, leading to increased intracellular lipid...
Pathway analysis revealed that the protein-encoding genes potentially regulate lipid metabolic reprogramming, and epithelial– mesenchymal transition (EMT). Expression of lipid metabolic-related genes LIPE, REEP6, GABRE, FBP1, SCD1, UGT2B11, APOC1 was confirmed by RT-qPCR. Functional analysis ...
The metabolic and lipidomic changes induced by COR alone or in combination with 2-DG were investigated using the human melanoma A375 and A2058 cells, which have different metastatic potentials, and primary HEMn-LP melanocytes by performing the GC-MS and DI-MS analyses. The GC-MS analysis det...