目前,有很多关于脂质分类的方法,但是根据结构和合成途径进行的分类最为准确。美国国立卫生研究院(NIH) 2003 年所资助的“脂质代谢途径研究计划”(Lipid metabolites and pathways strategy, LIPID MAPS)项目提出的脂质分类系统 (The LIPID MAPS Lipid Classification System),将脂质大体分为八大类: 1.脂肪酰(FA) 脂肪...
The LIPID Metabolites and Pathways Strategy (LIPID MAPS) Annual Meeting 2013: Impact of Lipidomics on Oxidized Lipids and Non-Alcoholic Fatty Liver Disease – the tenth annual meeting of the LIPID MAPS Consortium – was once again marked by beautiful Southern California weather, as top scientists ...
The Lipid Metabolites and Pathways Strategy Consortium (LIPID MAPS) has classified lipids into eight categories: fatty acyls (FA), glycerolipids (GL), glycerophospholipids (GP), sphingolipids (SP), sterol lipids (ST), prenol lipids (PR), saccharolipids (SL), and polyketides (PK) [13]. ...
67% methanol by volume to a final concentration of 10 μg/mL for analysis. Identification of lipids was based on exact mass measurements and the Lipid Metabolites and Pathways Strategy (LIPID MAPS) Structural Database (LMSD) and the Scripps Center for Metabolomics Metabolite Database (METLIN)...
lipids with abundances significantly altered by infection status were putatively identified using Human Metabolome Database (HMDB) and LIPID Metabolites and Pathways Strategy (LIPID MAPS) databases. Further compound validation was achieved by interpreting MS/MS spectra data when available. Representative MS...
On one hand, tumor cells can actively modify the TME by secreting signaling molecules and metabolites, which affect the functions of cancer-associated fibroblasts (CAFs) and immune cells in TME [6]. On the other hand, lipid metabolic reprogramming, an adaptive change in cells within the TME, ...
Seventy-two metabolites and 418 complex lipids were detected with a mean coefficient of variation around 12%, among which many were specific to the mitochondrial metabolism. Thus this strategy based on robust mitochondria-ER extraction and "omics" combination will be useful for investigating the ...
Enter LIPID MAPS, the website of the LIPID Metabolites And Pathways Strategy consortium (various other sites also exist, such as the European Lipidomics Initiative and LipidBank (a Japanese initiative)). This is a preview of subscription content, access via your institution Access options ...
Lipids are essential constituents for malignant tumors, as they are absolutely required for tumor growth and dissemination. Provided by the tumor microenvironment (TME) or by cancer cells themselves through activation of de novo synthesis pathways, they
Lipid metabolism refers to the process of digestion, absorption, synthesis, and decomposition of fats in living organisms by various enzymes. The metabolites include adipokines, fatty acids, and cholesterol substances. Adipokines regulate the endocrine metabolic functions of adip...