层次聚类分析结果表明,D-gal处理后某些基因的表达模式发生改变,而XSD治疗后这些改变得到逆转(Fig. 5B)。GO富集分析结果显示,D-gal组与D-gal + XSDH组差异表达基因主要与“线粒体呼吸链”“线粒体内膜”“线粒体蛋白复合物”等相关;KEGG富集分析结果与“PI3K-Akt信号通路”“P53信号通路”“氧化磷酸化”等相关(...
upregulation of expression in HFD+POM-cotreated mice compared to HFD-treated mice (). KEGG pathway analysis revealed that metabolic pathways and the AMPK signaling pathway were the main pathways upregulated by POM treatment (). Moreover, lipid and carbohydrate metabolism were strongly affected by ...
4. 差异基因进行KEGG富集分析 筛选后,我们使用在线Omic Share Tools进行KEGG富集分析,标准为p < 0.05和Q < 0.05,研究某些功能类型的差异表达蛋白是否存在显著富集趋势。与本研究相关的三类中遗传信息加工(含5个途径)、环境信息加工(含...
On the other hand, the 48822 KEGG pathway enrichment results (Figure 2(b)) illustrated that the functional module genes are chiefly engaged in the AMPK signaling pathway, apoptosis, the PI3K-Akt signaling pathway, and the NF-kappa B signaling pathway. These signaling pathways have been proved ...
Furthemore, given the role of the AK-AMP-AMPK signaling pathway in monitoring energy metabolism, we incorporated the AMPK signaling pathway gene set into subsequent GSVA and KEGG pathway analyses to assess the impact of AK5 alterations on AMPK signaling. Single-cell sequencing shows AK5 ...
GNA15 regulates FAO process by activating AMPK signaling pathway The KEGG enrichment analysis of the untargeted metabolomics also suggested differential metabolites of ALL cell lines was enriched in AMPK signaling pathway, which is a key signaling pathway for regulating FAO process (Fig. 5C). Later ...
Result 4 GO和KEGG分析鉴定与虫草素和顺铂联合治疗食管癌相关的蛋白质和信号通路 使用PharmMapper,作者获得了虫草素300个潜在蛋白质靶点的信息,有研究表明虫草素可通过激活AMP活化蛋白激酶(AMPK)信号传导抑制脂多糖(LPS)诱导的肿瘤坏死因子-...
(C) KEGG pathway enrichment of DEGs. (D) Heatmap of differentially expressed genes (DEGs). 3.6. XLLX enhances the expression of PPARγ and p-AMPK in TNBC cells, tumors, and metastatic lung tissue It has been reported that the PPARγ/AMPK signaling pathway plays a crucial role in the ...
KIAA1363 Regulates an Ether Lipid Signaling Network that Bridges Platelet-Activating Factor and the Lysophospholipids Examination of the Kyoto Encyclopedia of Genes and Genomes (KEGG) database[26]suggests that the KIAA1363-MAGE pathway might serve as a unique metabolic node linking the PAF[27]and ...
In addition, while we have conducted preliminary investigations into the regulatory role of the APN-AdipoR1 signaling pathway on ferroptosis, more comprehensive evidence is required to elucidate the underlying mechanisms, particularly concerning the influence of the APN-AdipoR1 axis on PUFA biosynthesis....