Myrrh, as a traditional natural medicine, is an aromatic gum resin, which was the plant stem resin- ous exudate of Commiphora myrrha (Nees) Engl. (Burseraceae) and various other different species of Commiphora family. It has many medicinal powers and has been used widely in clinic for ...
针对钙化性主动脉瓣疾病(CAVD)缺乏有效治疗手段的难题,浙江大学团队聚焦前列腺雄激素调节黏蛋白样蛋白1(PARM1)在瓣膜间质细胞(VICs)成骨分化中的作用,通过多组学分析和体内外实验,首次揭示PARM1通过PRKCH-MAPK信号通路促进VICs成骨分化和瓣膜钙化,为CAVD治疗提供了新靶点。 随着人口老龄化加剧,钙化性主动脉瓣疾病(CAV...
KEGG pathways analysis showed the 78 genes mainly enriched in to signal transduction pathways, espe- cially in MAPK signaling pathway (ko04016) and plant hormone signal transduction pathway (ko04075) (Fig. 10a, b, Additional file 13 Fig. S8c). Protein interactions among DEGs was detected ...
"RNA-seq and DEG analysis"揭示AMH调控网络包含1486个差异基因,KEGG分析显示细胞周期和MAPK通路显著富集。特别在"AMH regulats cell cycle and inhibits steroid hormone synthesis of GCs"部分,CCND1、CCNE2等细胞周期基因受AMH正向调控,而雌激素合成关键酶CYP19A1的mRNA水平在AMH敲除后上升2.3倍(P<0.001)。最终在...
and starvation inT. reesei. This analysis was performed using the KEGG MAPK signaling pathway in Yeast (https://www.genome.jp/kegg/pathway/sce/sce04011.html) as reference. (B) Heatmap showing expression of the differentially expressed genes belonging to the MAPK signaling pathway in theT. ree...
phenylpropanoid biosynthesis, starch and sucrose metabolism, flavonoid biosynthesis, plant hormone signal transduction, and the MAPK signaling pathway. Validation of the 17 selected transcripts showed a strong positive correlation (p < 0.05) between RNA sequencing and NanoString nCounter results. This...
GO and KEGG pathway enrichment analysis of 110 tandem targets were conducted using the DAVID database (Fig. 7A-E). Based on network pharmacological analysis, we found that MAPK signaling pathway may be one of the most relevant signaling pathways for QGY treatment of PMOP. This is consistent wi...
Lin et al. warned that nanoparticles may be transferred through food chains to higher trophic levels, including humans, and believed that plant uptake may be a critical pathway for the of nanoparticles into the food chain (Lin et al., 2010). Al-Salim et al. also reported on the transport...
c Regulated pathway prediction of β-elemene on HFD-induced DEGs (p.adjust: p-value after correction, Gene Ratio: the proportion of genes enriched in the biological processes). d Descriptions of KEGG pathways. e Interaction between regulated pathways and targets of β-elemene on HFD- induced ...
0.05 (Supplementary Data1). Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analysis revealed significant enrichment of DEGs involved in plant-pathogen interaction and the MAPK signalling pathway (Fig.2a). These results suggest that the P7 protein likely activates the plant MPK3/6 pathway...