To further elucidate the underlying signaling pathways modulated by RA in MM, the study conducted an analysis of KEGG pathways. KEGG pathway enrichment analysis predicted that in addition to the PI3K/AKT pathway which has been reported19, the MAPK signaling pathway was one of the pathways closely...
Our results suggest that miRNAs may alter MAPK signaling through direct binding with key genes in this pathway. We encourage others to validate results in targeted CRC experiments that can help solidify important therapeutic targets. 展开 关键词: MAPK, colorectal cancer, miRNA, mRNA, ERK1/2 ...
In addition, we discuss some antigenic proteins as prospective inhibitory molecules or vaccines for the regulation and control of MAPK signaling involved in parasite physiological activity. 展开 关键词: MAPK, mitogen-activated protein kinase, transduction pathway, parasite ...
Su, S., Duan, J., Chen, T.et al.Frankincense and myrrh suppress inflammation via regulation of the metabolic profiling and the MAPK signaling pathway.Sci Rep5, 13668 (2015). https://doi.org/10.1038/srep13668 Download citation Received31 March 2015 ...
aЛексикаиграмматика 词汇量和语法[translate] aGuaLou GuiZhi decoction inhibits LPS-induced microglial cell motility through the MAPK signaling pathway GuaLou GuiZhi滴露通过MAPK信号路禁止LPS导致的microglial细胞能动性[translate]...
The mitogen-activated protein kinase (MAPK) pathway is frequently activated in human cancers, leading to malignant phenotypes such as autonomous cellular proliferation. Here, we demonstrate a novel role of the activated MAPK pathway in immune evasion by melanoma cells with the mutation of BRAF, w...
The MAPK/ERK1/2 pathway is maintained active in the IS by testicular luminal factors and plays crucial roles in the maintenance and differentiation of the IS epithelium. Tight junctions (TJs) are constituents of the blood-epididymis barrier, which mediates the paracellular transport of ions, ...
摘要: We utilize an agent-based approach to model the MAPK signaling pathway, in which we capture both individual and group behaviour of the biological entities inside the system. In an effort to adaptively reduce complexity of interactions among the simulated agents, we......
There is also increasing evidence that MAPK is an important regulator of ischemic and hemorrhagic cerebral vascular disease, raising the possibility that it might be a drug discovery target for stroke. In this review, we discuss the MAPK signaling pathway in association with its activation in ...
The MAPK signaling pathway Mitogen-activated protein kinase (MAPK) cascades are complex signaling pathways that regulate various cellular activities, including inflammation, apoptosis, proliferation, and differentiation. There are three major subfamilies in the MAPK family: extracellular-signal-regulated kinase...