AMPK Signaling Pathway
The potential of AMPK to regulate neurodegenerative disorders lies in its ability to enhance antioxidant capacity, reduce oxidative stress, improve mitochondrial function, decrease mitophagy and macroautophagy, and inhibit inflammation. In addition, it has been shown that modulating the ca...
View Proteintech's AMPK signaling pathway poster or request a printed copy for your lab. AMPK is a master regulator of cellular energy homeostasis and has recently been connected to cellular processes such as autophagy and cell polarity
Mechanically, MCT significantly increased the level of UCP1, AMPK, and the downstream signaling factors of Pgc1伪 and Ulk1 , further significantly elevated the brown differentiation factor of Ppar纬 . Moreover, The AMPK inhibitor dorsomorphin partially impaired the beneficial effects caused by MCT. ...
AMPK. Finally, the results of in vivo study conducted in high fat diet-fed rats were consistent with the findings of in vitro study. In conclusion, DHM improved SMIR by inducing autophagy via the activation of AMPK signaling pathway. ...
(AMPK)-sirtuin 1 (SIRT1) signaling pathway was involved in the anti-arthritic ef f ects of BB. In vitro, block-ing BB’s chondroprotection with the AMPK-specif i c inhibitor Compound C abrogated it.Conclusions: These results demonstrated that BB extracted from Gingko biloba regulates ECM ...
Furthemore, given the role of the AK-AMP-AMPK signaling pathway in monitoring energy metabolism, we incorporated the AMPK signaling pathway gene set into subsequent GSVA and KEGG pathway analyses to assess the impact of AK5 alterations on AMPK signaling. Single-cell sequencing shows AK5 ...
Then, we confirmed the effect of omentin-1 on the AMPKα/mTOR signaling pathway in vitro. As expected, FFA decreased the level of p-AMPKα and increased mTOR expression, and this trend was mitigated by the administration of omentin-1. Meanwhile, these alterations mediated by omentin-1 ...
Cardiac hypertrophy is a common adaptive response to a variety of stimuli, but prolonged hypertrophy leads to heart failure. Hence, discovery of agents treating cardiac hypertrophy is urgently needed. In the present study, we investigated the effects of
Further analysis showed that DMC activated the SIRT1/AMPK signaling pathway in vivo and in vitro. Our data showed that SIRT1 knockdown downregulated NLRX1 expression, leading to structural damage and functional impairment in mitochondria, as well as increased oxidative stress, inflammatory response, ...