来自“The AMP-activated protein kinase (AMPK) signaling pathway coordinates cell growth, autophagy, & metabolism” 在营养缺乏的情况下,AMPK是抑制细胞生长的代谢检查点。这一机制是通过抑制mTORC1通路实现的。AMPK可以直接磷酸化Raptor,阻断mTORC1激酶复合物
hepatic gluconeogenesis and improve IR via activating AMPK signaling pathway in T2DM mice. Reference: SONG M X, TAN D H, LI B, et al. Gypenoside ameliorates insulin resistance and hyperglycemia via the AMPK-mediated sign...
et al. AMPK modulates Hippo pathway activity to regulate energy homeostasis. Nat. Cell Biol. 17, 490–499 (2015). 98. Rutherford, C. et al. Phosphorylation of Janus kinase 1 (JAK1) by AMP-activated protein kinase (AMPK) links energy sensing to anti-inflammatory signaling. Sci. Signal. ...
Chalcones suppress fatty acid-induced lipid accumulation through a LKB1/AMPK signaling pathway in HepG2 cells The flavonoid 4,4′-dimethoxychalcone promotes autophagy-dependent longevity across species 虾青素改善糖尿病可能与刺激脂联素分泌有关_301医院_母义明_主任 AMPK...
脂肪间充质干细胞来源的细胞外囊泡通过 CBL/AMPK 通路缓解急性肺损伤:开拓肺部疾病治疗新方向 《BMC Biology》:Extracellular vesicles from adipose-derived mesenchymal stem cells alleviate acute lung injury via the CBL/AMPK signaling pathway 编辑推荐:
PMID: 35001345. 原文链接:Vaspin attenuates steatosis-induced fibrosis via GRP78 receptor by targeting AMPK signaling pathway - PubMed 小编旨在分享、学习、交流生物科学等领域的研究进展。如有侵权或引文不当请联系小编修正。 微信搜索公众号“Naturethink”,了解更多细胞体外仿生培养技术及应用。
参考文献:Abdolahi A, Vahabzadeh Z, Izadpanah E, Moloudi MR. Vaspin attenuates steatosis-induced fibrosis via GRP78 receptor by targeting AMPK signaling pathway. J Physiol Biochem. 2022 Feb;78(1):185-197. doi: 10.1007/s13105-021-00852-7. Epub 2022 Jan 10. PMID: 35001345. ...
本文就 AMPK 的结构和功能、在骨组织细胞中的作用、与成骨成脂分化平衡的关系作一综述,并分析 AMPK 通路作为骨质疏松症潜在治疗靶点的可能性。关键词: 腺苷酸活化蛋白激酶(AMPK);能量代谢;骨代谢;骨质疏松症The regulatory role of AMPK signaling pathway in bone metabolismWANG Yugang, FAN Qiming, TANG Tingtin...
2022年,中国科技大学的吴家伟等人,在International Journal of Biological Sciences(IF2022=10.75,生物2区)发表了题为“ATPase inhibitory factor 1 protects the heart from acute myocardial ischemia/reperfusion injury through activating AMPK signaling pathway”的文章,研究了IF1对心肌缺血再灌注损伤的保护作用,以及AMPK...
原名：Exosomes generated from bone marrow mesenchymal stem cells limit the damage caused by myocardial ischemia-reperfusion via controlling the AMPK/PGC-1α signaling pathway 期刊：Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease 影响因子：中科院2区, IF4.2 发表时间：2025年5月 研究...