12月18日Nature的研究报道“Lithocholic acid binds TULP3 to activate sirtuins and AMPK to slow down ageing”,聚焦于LCA通过溶酶体信号通路(lysosomal signaling pathway)激活AMPK的机制。通过一系列生化、分子和动物实验,研究人员发现,LCA能够增强去...
et al. Targeting energy metabolic and oncogenic signaling pathways in triple-negative breast cancer by a novel adenosine monophosphate- activated protein kinase (AMPK) activator. J. Biol. Chem. 286, 39247–39258 (2011). 234. Huang, X. et al. Important role of the LKB1-AMPK pathway in ...
来自“The AMP-activated protein kinase (AMPK) signaling pathway coordinates cell growth, autophagy, & metabolism” 在营养缺乏的情况下,AMPK是抑制细胞生长的代谢检查点。这一机制是通过抑制mTORC1通路实现的。AMPK可以直接磷酸化Raptor,阻断mTORC1激酶复合物磷酸化其底物的能力。当然mTOR还参与细胞自噬过程。 LKB1...
hepatic gluconeogenesis and improve IR via activating AMPK signaling pathway in T2DM mice. Reference: SONG M X, TAN D H, LI B, et al. Gypenoside ameliorates insulin resistance and hyperglycemia via the AMPK-mediated sign...
Calcium-Oxidant Signaling Network Regulates AMP-activated Protein Kinase (AMPK) Activation upon Matrix Deprivation. J Biol Chem. 2016 Jul 8; 291(28): 14410–14429. 6. Simon A. Hawley, et al. Phosphorylation by Akt within the ST loop of AMPK-α1 down-regulates its activation in tumour ...
View Proteintech's AMPK signaling pathway poster or request a printed copy for your lab. AMPK is a master regulator of cellular energy homeostasis and has recently been connected to cellular processes such as autophagy and cell polarity
96. DeRan, M. et al. Energy stress regulates Hippo-YAP signaling involving AMPK-mediated regulation of angiomotin-like 1 protein. Cell Rep. 9, 495–503 (2014). 97. Wang, W. et al. AMPK modulates Hippo pathway activity to regulate energy homeostasis. Nat. Cell Biol. 17, 490–499 (2015...
AMPK Signaling Pathway
禁食、二甲双胍不如它！Science：AMPK与线粒体合成关键蛋白破解 目前应用最广泛的间歇性禁食、运动等延寿方式，目标都是减少细胞内的糖分等营养物质，通过“饿着细胞”来激活AMPK。而AMPK延寿的关键是促进“细胞发电厂”线粒体的合成，以保持机体年轻时的代谢水平。但再仔细想想，AMPK是如何激活线粒体的？我们能不能...
TheregulatoryroleofAMPKsignalingpathwayinbonemetabolism WANGYugang,FANQiming,TANGTingting ShanghaiKeyLaboratoryofOrthopedicImplants,DepartmentofOrthopedicSurgery,ShanghaiNinthPeople’sHospital,Schoolof Medicine,ShanghaiJiaotongUniversity,Shanghai200011,China