AMPK的这种双重调控过程可以用新的功能性线粒体替换缺陷性的线粒体,实现线粒体的“净化作用”,在许多生理及病理中起到关键作用。 AMPK信号通路 AMPK信号通路 来自“The AMP-activated protein kinase (AMPK) signaling pathway coordinates cell growth, autophagy, & metabol
et al. Targeting energy metabolic and oncogenic signaling pathways in triple-negative breast cancer by a novel adenosine monophosphate- activated protein kinase (AMPK) activator. J. Biol. Chem. 286, 39247–39258 (2011). 234. Huang, X. et al. Important role of the LKB1-AMPK pathway in ...
研究人员发现,LCA可以通过溶酶体信号通路(lysosomal signaling pathway)直接激活AMPK(AMP-活化蛋白激酶),从而模拟CR带来的代谢和抗衰老效益。这种机制的独特之处在于,LCA并非通过改变细胞内AMP/ATP或ADP/ATP的比值,而是通过溶酶体的葡萄糖感应系统来触发A...
激活AMPK不仅可以调节生物能量代谢(可改善高血压、高血糖、高胆固醇、高血脂),还具有抗抑郁和神经保护作用(具有促进线粒体自噬和合成,减少脑内淀粉样蛋白、增加脑源性神经营养因子<BDNF>等作用),并且能激活抑癌基因pP53和延长端粒相关机制。 同时,AMPK激活剂可以抑制NAD+消耗酶...
本文就 AMPK 的结构和功能、在骨组织细胞中的作用、与成骨成脂分化平衡的关系作一综述,并分析 AMPK 通路作为骨质疏松症潜在治疗靶点的可能性。关键词: 腺苷酸活化蛋白激酶(AMPK);能量代谢;骨代谢;骨质疏松症The regulatory role of AMPK signaling pathway in bone metabolismWANG Yugang, FAN Qiming, TANG Tingtin...
PMID: 35001345. 原文链接:Vaspin attenuates steatosis-induced fibrosis via GRP78 receptor by targeting AMPK signaling pathway - PubMed 小编旨在分享、学习、交流生物科学等领域的研究进展。如有侵权或引文不当请联系小编修正。 微信搜索公众号“Naturethink”,了解更多细胞体外仿生培养技术及应用。
Conclusion Acute kidney injury in mice can activate the AMPK signaling pathway and induce the expression of AMPK and Keap-1 increase,which leads to the deterioration of renal tissue and renal function. 【Key words】 Mice Acute kidney injury Adenosine phosphate activating protease Renal function 急性...
autophagyanddampenedbactericidalactivity.ConclusionAMPKanditsrelatedsignalingpathwayisrequiredforanti bacterialresponsein macrophage,whichisdependentonitsfunctioninupregulatingautophagyrelatedmoleculesandinducingautophagy. Kewords:AMPK;murinebonemarrowderivedmacrophages(BMDM);antibacterialautophagy 自噬(autophagy)是一种细胞内的...
Key words: loganin; hepatic lipid metabolism disorders; fructose diet; AMPK signaling pathway; fatty acid synthesis 非酒精性脂肪性肝病(non-alcoholic fatty liver disease,NAFLD)是以肝脏脂代谢紊乱导致肝细胞 内过量脂质蓄积引起肝脏脂肪样变性为主要特征的 临床病理综合征[1].调查显示,NAFLD 已成为全球 最...