但当前尚不清楚ALK阳性NSCLC中PD-L1表达情况对ALK-TKI疗效的影响[1]。2024年美国临床肿瘤学会(ASCO)大会上公布的题为“High PD-L1 expression among patients with ALK rearranged non-small cell lungcancer and response to first line ALK ...
11 Ryoko Inaba-Higashiyama, Tatsuya Yoshida, Hitomi Jo, et al. Clinical outcomes of pembrolizumab therapy in advanced-NSCLC patients with poor performance status (≥ 3) and high PD-L1 expression (TPS ≥ 50%): A case series[J]. Thoracic Cancer, 11 (2020) 3618–3621. doi: 10.1111/1759-77...
High expression of PD-L1 in lung cancer may contribute to poor prognosis and tumor cells immune escape through suppressing tumor infiltrating dendritic cells maturation. Med Oncol. 2011; 28 :682–8. doi: 10.1007/s12032-010-9515-2. [ Cross Ref ]...
Wu F, Liu M. Case Report: Intervention of radiotherapy improves the prognosis of rectal squamous cell carcinoma with high PD-L1 expression and enable patients to obtain NED status. Front Immunol. 2023 Jul 14;14:1235697. doi: 10.3389/fimmu.2023.1235697. PMID: 37520582; PMCID: PMC10382127....
英文摘要: OBJECTIVE:To ev aluate the economics of pembrolizumab versus first-line chemotherapy in the treatment of advanced non-small cell lung cancer with high programmed cell death protein ligand 1(PD-L1)expression from the perspective of Chinese healthcare system. METHODS :Published KEYNOTE- 042...
Patients with advanced BTC (n = 175) were screened for PD-L1 expression using PharmDx assay and microsatellite instability (MSI) status. Of the total of 175 patients, 125 (71%) showed tumoral PD-L1 positivity (≥ 1%) while only two (2/142, 1.4%) showed MSI-High. Among 175 ...
High PD-L1 expression correlated with poor prognosis and may provide a rationale for immunotherapy for high-grade SCLC. 展开 关键词: small cell lung cancer, immunotherapy, programmed cell-death ligand 1, stage, overall survival DOI: 10.18632/oncotarget.14935 被引量: 12 ...
英文标题:Phase II study of atezolizumab with bevacizumab for non-squamous non-small cell lung cancer with high PD-L1 expression (@Be Study) 杂志名称:Journal for immunotherapy of cancer 影响因子:13.751 发布日期:2022年02...
[1]Microsatellite instability (MSI-H) is associated with a high immunoscore but not with PD-L1 expression or increased survival in patients (pts.) with metastatic colorectal cancer (mCRC) treated with oxaliplatin (ox) and fluoropyrimidine (FP) with and without bevacizumab (bev): a pooled analy...
Qin T, Zeng YD, Qin G, et al. High PD-L1 expression was associated with poor prognosis in 870 Chinese patients with breast cancer. Oncotarget. 2015;6(32):33972-33981. DOI: 10.18632/oncotarget.5583 Sun WY, Lee YK, Koo JS. Expression of PD-L1 in triple-negative breast cancer based on...