PD-L1 expressionProgrammed death-ligand 1 (PD-L1), expressed on the surface of tumor cells, can bind to programmed cell death-1 (PD-1) on T cells. The interaction of PD-1 and PD-L1 can inhibit T-cell responses by decreasing T-cell activity and accelerating their apoptosis. Various ...
PD-L1 或可用作预后标志物,73-10 和 SP263 是进一步研究的最佳候选者,这是标准化 CRC PD-L1 评估所需要的。 参考文献: Nobin H, Garvin S, Hagman H, Nodin B, Jirström K, Brunnström H. The prognostic value of programmed death-ligand 1 (PD-L1) expression in resected colorectal cancer wit...
Objective To study the expression of PD-1 and PD-L1 in different differentiated primary hepatocellular carcinoma(HCC),and to analyze the relationship between the expression of PD-1 and PD-L1 and the clinicopathological characteristics and prognosis of HCC. Method Immunohistochemical staining was used ...
PD-1/PD-L1–targeted immunotherapy has emerged as a promising therapeutic strategy for pulmonary adenocarcinoma (pADC). Epithelial-to-mesenchymal transition (EMT) is involved in the progression and immune evasion of cancers. Therefore, we investigated the association between PD-L1 expression and EMT ...
Programmed death 1 ligand 1 (PD-L1) is an immune regulatory molecule that limits antitumor immune activity. Targeting of PD-L1 and other immune checkpoint proteins has shown therapeutic activity in various tumor types. The expression of PD-L1 and its correlation with response to neoadjuvant chemoth...
Molecular mechanisms of programmed death-ligand 1 (PD-L1) mRNA expression and roles of apoptosis and biomarkers are poorly understood in epidermal growth factor receptor (EGFR)-mutant lung adenocarcinoma patients. Thirty-three patients with recurrent postoperative EGFR-mutant lung adenocarcinoma (exon 19...
Notably, the different immunosuppression capacities of WJ-MSCs were positively correlated with PD-L1 expression. WJ-MSCs with high expression of PD-L1 were therapeutically superior to WJ-MSCs with low PD-L1 expression in treating autoimmune hepatitis. Conclusion PD-L1 expression levels of WJ-MSCs ...
近日,来自美国哥伦比亚大学的Alberto Ciccia研究小组在Cell杂志上发表题为SMARCAL1 is a dual regulator of innate immune signaling and PD-L1 expression that promotes tumor immune evasion的研究论文,这篇文章发现DNA易位酶SMARCAL1通过两种...
而SMARCAL1对PD-L1表达水平的影响,则涉及表观遗传层面的染色质可及性,相对独立于其参与DNA损伤应答的机制:敲除SMARCAL1后,PD-L1基因染色质上的3个关键调控区域,特别是上调PD-L1表达的P3区域将不再可及,意味着SMARCAL1可诱导癌细胞的PD-L1表达上调,而SMARCAL1要发挥这种作用,不仅需要保留自身的ATP酶活性,还...
We identified that PD-L1 negatively regulates the frequency of iNKT cell subsets in the lungs of IAV infected mice. Altogether, these results demonstrate that lack of PD-L1 expression by iNKT cells reduces the sensitivity to IAV and that the presence of PD-L2 is important for dampening the ...