[6].Lastwika KJ, Wilson W, Li QK, Norris J, Xu H, Ghazarian SR, et al. Control of PD-L1 expression by oncogenic activation of the AKT-mTOR pathway in non-small cell lung cancer. Cancer Research. 2016 Jan ...
表达(Expression) Naive T细胞在TCR信号通路激活的时候,会飞快地表达PD-1。而当T细胞被连续不断地刺激时,T细胞会变成exhausted T,会持续性地表达很高的PD-1。 除了在CD4, CD8 T细胞上有表达,PD-1在Treg, B, NK, NKT细胞也有表达。 目前已知的PD-1的ligand有两个: PD-L1 (CD274) PD-L2 (CD273) 和PD-...
[7]. Kumagai S,Togashi Y, Kamada T, et al. The PD-1 expression balance between effector andregulatory T cells predicts the clinical efficacy of PD-1 blockadetherapies[J]. Nature Immunology, 2020, 21(11): 1346-1358.封面图来源：摄图网 ...
这是由TCR信号通路激活所诱导;但是,在肿瘤浸润性T细胞中,PD-1的表达异常升高却非TCR信号通路主导。 3月12日,中国医学科学院基础医学研究所&北京协和医学/华中科技大学同济医学院生物化学与分子生物学系教授黄波课题组在Cancer Cell杂志上发表了了题为“Tumor-Repopulating Cells Induce PD-1 Expression in CD8+ T C...
斯坦福大学医学院科学家Weissman和同事的题为《PD-1 expression by tumor-associated macrophages inhibits phagocytosis and tumor immunity》的研究表明,PD-1/PD-L1抗体可通过促使巨噬细胞吞噬癌细胞抗击癌症。该研究结果被发表于2017年的《自然》杂志。 Wei...
2022年1月27日，日本国立癌症研究中心Hiroyoshi Nishikawa教授领衔在Cancer Cell杂志发表了题为Lactic acid promotes PD-1 expression in regulatory T cells in highly glycolytic tumor microenvironments的研究长文，通过从代谢角度研究TME中表达PD-1的效应T细胞和Treg细胞间稳态平衡的影响因素，发现乳酸能够作为Treg细胞的...
(PD-L1) expression or tumor mutational burden. PD-1 expression by CD8+T cells and Tregcells negatively impacts effector and immunosuppressive functions, respectively. PD-1 blockade induces both recovery of dysfunctional PD-1+CD8+T cells and enhanced PD-1+Tregcell–mediated immunosuppression. A ...
(PD-L1) expressed on tumor cells, enable cancers to evade the immune system. Blocking PD-1 with the monoclonal antibody pembrolizumab is a promising immunotherapy strategy. Thus, noninvasively quantifying the presence of PD-1 expression in the tumor microenvironment prior to initiation of immune ...
如果在传统的放化疗时，偶尔来这么一两个疗程，说不定会有奇效。参考文献：Iwata T ,et al., Complete Response Achieved 1 Year after a Single Administration of Nivolumab in a Patient with Lung Adenocarcinoma with Negative Expression of PD-L1. J Thorac Oncol. 2017 Dec;12(12):e205-e207.
Gordon, S. R., et al. (2017). "PD-1 expression by tumour-associated macrophages inhibits phagocytosis and tumour immunity" Nature 545(7655): 495-499.in vivo blocking of PD-1/PD-L signaling, Flow Cytometry Koyama, S., et al. (2016). "Adaptive resistance to therapeutic PD-1 blockade ...