PD-1单抗的制备及逆转Jurkat细胞免疫抑制的作用及机制研究 热度: 藏红花素对Jurkat细胞抑增殖作用及机制研究 摘要 目的 探讨藏红花素(crocin)对人急性T淋巴细胞白血病细胞株(Jurkat细胞)抑 增殖及作用机制。 方法 实验分为对照组与实验组,实验组按照crocin终浓度分为A组(0.625mg/m1)、 ...
• Raji-target cells (CTLA-4, PD-1, ICOS..) Jurkat-Lucia™ NFAT-CD16 cells and Jurkat-Lucia™ NFAT-CD16-Low cells were engineered from the human T lymphocyte Jurkat cell line to assess the potency of specific antibodies/immunoglobulin for antibody-dependent cellular cytotoxicity (ADCC):...
Jurkat cells are a human immortalized T lymphocyte cell line derived from an acute T cell leukemia. Jurkat cells are used to study T cell signaling and the expression of various chemokine receptors susceptible to viral entry, particularly HIV.
Construction and Expression of Anti-CD3/ Anti-Pgp Diabody抗CD3/抗Pgp微型双功能抗体的构建和表达 的产量达 2mg L以上 ,纯化产物中二聚体的比例达 90 % ,具有与Jurkat(CD3 + )和K5 62 A0 2细胞 (Pgp+ )结合的活性 ,与抗CD3ScFv及抗PgpScFv的亲合... 熊冬生 - 《生物工程学报》 被引量: 0发表:...
Recently, the miR-138 was reported as a PD-L1 regulator in NSCLC. However, its inhibitory impact on T-cell exhaustion has not been characterized. The present study aims to impair PD-L1 (B7-H1) expression in Adenocarcinoma cell lines using miR-138-5p and determines how it prevents Jurak ...
Our results are similar to the previous report that Glut1 expression increased following T cell activation and decreased in exhausted T cells expressing PD-1 [32]. We ruled out the role of sodium-glucose linked transporter 1 (SGLT1), which are efficient at low extracellular glucose ...
This cell line has been engineered for use with the CRISPR Synergistic Activation Mediator (SAM) system to induce transcriptional activation and expression of any gene of interest. Cells stably express a mutated dCas9 (Streptococcus pyogenes CRISPR assoc
(mu)CTLclonederivedfromimmunizedTgmice,whichrecognized endogenouslyprocessedhup53restrictedbyHLAA*0201.Theseparate AandBchainTCRcDNAsweretransfectedinthecorrespondingTCR A andB Jurkat-CD3 mutantT-celllines,andeachrescuedCD3 surfaceexpression.BothTCRchainsweresimultaneouslyintroducedinto Jurkat-CD3 cells,andthe...
人T淋巴细胞白血病细胞Jurkat,货号:TCH-C225-1X10^6 该细胞是Jurkat-FHCRC细胞株(Jurkat细胞株的衍生)的一个克隆。Jurkat细胞株来源于一个14岁男孩的外周血;经佛波酯和外源凝集素或抗T3单克隆抗体中的一种诱导后可产生大量IL-2(IL-2的产生需两种类型的诱导剂);表达T细胞受体、CD3。 细胞名称:人T淋巴细胞白血病...
Collectively, our studies show that the Nrf2 activator, tBHQ, inhibits IL-2 and CD25 expression, which correlates with decreased NFκB transcriptional activity in activated Jurkat cells. Overall, our studies suggest that Nrf2 represents a novel mechanism for the regulation of both human and mouse T...