[6] Perol, M., E. Felip, U. Dafni, et al., Effectiveness of PD-(L)1 inhibitors alone or in combination with platinum-doublet chemotherapy in first-line (1L) non-squamous non-small-cell lung cancer (Nsq-NSCL...
Effectiveness of PD-(L)1 inhibitors alone or in combination with platinum-doublet chmotherapy in first-line (1L) non-squamous non-small-cell lung cancer (Nsq-NSCLC) with PD-L1-high expression using real-world data. Ann Oncol. 2022 May;33(5):511-521....
研究发现,放射治疗可直接损伤肿瘤细胞的DNA,刺激新的抗原产生,上调肿瘤微环境中趋化因子CXCL10和CXCL16的表达水平,促进细胞毒性T淋巴细胞向肿瘤迁移,增强靶细胞表面PD-L1的表达,提高抗PD-L1治疗的效果。此外,树突状细胞的PD-L1表达是肿瘤中T细胞免疫的关键调节因子,局部高剂量照射导致肿瘤相关树突状细胞的活化,进而导致...
研究发现,放射治疗可直接损伤肿瘤细胞的DNA,刺激新的抗原产生,上调肿瘤微环境中趋化因子CXCL10和CXCL16的表达水平,促进细胞毒性T淋巴细胞向肿瘤迁移,增强靶细胞表面PD-L1的表达,提高抗PD-L1治疗的效果。此外,树突状细胞的PD-L1表达是肿瘤中T细胞免...
Further, high PD-L1 expression on cDC1 in TDLNs was associated with metastasis and/or recurrent disease risk. Also, elevated levels of memory CD8 T-cells and terminally exhausted PD-1 TCF-1CD8 T-cells were observed in TDLNs and non-TDLNs compared to healthy lymph nodes. Conclusions: We ...
【1】Hsu KH, Huang YH, Tseng JS, Chen KC, Ku WH, Su KY, Chen JJW, Chen HW, Yu SL, Yang TY, Chang GC. High PD-L1 expression correlates with primary resistance to EGFR-TKIs in treatment naïve advanced EGFR-mutant lung adenocarcinoma patients. Lung Cancer. 2019 Jan;127:37-43. doi...
High expression of PD-L1 in tumor cells contributes to tumor immune evasion. However, whether PD-L1 expression in tumor cells is regulated by the availability ofnutrientsis unknown. Here, we show that in human glioblastoma cells, high glucose promotes hexokinase (HK) 2 dissociation frommitochondria...
[6] Li M , Hou X , Chen J , et al. ALK fusion variant 3a/b, concomitant mutations, and high PD-L1 expression were associated with unfavorable clinical response to second-generation ALK TKIs in patients with advanced ALK-rearranged non-small cell lung cancer (GASTO 1061)[J]. Lung Cance...
英文摘要: OBJECTIVE:To ev aluate the economics of pembrolizumab versus first-line chemotherapy in the treatment of advanced non-small cell lung cancer with high programmed cell death protein ligand 1(PD-L1)expression from the perspective of Chinese healthcare system. METHODS :Published KEYNOTE- 042...
Patients with advanced BTC (n = 175) were screened for PD-L1 expression using PharmDx assay and microsatellite instability (MSI) status. Of the total of 175 patients, 125 (71%) showed tumoral PD-L1 positivity (≥ 1%) while only two (2/142, 1.4%) showed MSI-High. Among 175 ...