Higher densities of CD3+ (p = 0.01), CD8+ (p = 0.006), and PD-1+ (p = 0.024) tumor-associated T cells were associated with higher T category (≥T3a per the 7th edition of the American Joint Committee on Cancer staging manual). Higher tumor cell expression of PD-L1 ...
To analyze the mismatch repair (MMR) status and PD-L1 expression in nasopharyngeal carcinoma (NPC), and investigate whether PD-L1 and MMR status could be used as a biomarker for predicting response of immune checkpoint blockades (ICBs) treatment.A total of 108 patients were initially histopatholo...
Pembrolizumab appears promising for patients with programmed cell death ligand-1 (PD-L1)-positive solid tumors. However, data on immunotherapy for biliary tract cancers (BTC) are limited. We aimed to investigate the predictive value of PD-L1 expression as an immunotherapeutic biomarker in BTC. Pati...
PD-1 expression on CD8 T cells was increased in the first year post-transplant irrespective of EBV outcome, and most CD8 T cells continued to express PD-1 for up to three yr post-transplant. Although all patient groups showed similar frequencies of EBV-specific CD8+ T cells, PD-1 ...
The aggressive behavior of SCLC could be partially related to PD-L1-mediated immune escape. High PD-L1 expression correlated with poor prognosis and may provide a rationale for immunotherapy for high-grade SCLC. 展开 关键词: small cell lung cancer, immunotherapy, programmed cell-death ligand 1, ...
Cell-intrinsic PD-1 and PD-L1 were found to be expressed in a large variety of cancer cells, with particularly high PD-1 expression in 13 tumor types and 40 tumor cell lines, including cervical cancer lines [11]. In this study, we evaluated the expression of PD-1 and PD-L1 in the ...
Real-World Safety and Outcome of First-Line Pembrolizumab Monotherapy for Metastatic NSCLC with PDL-1 Expression ≥ 50%: A National Italian Multicentric Co... Simple Summary: Pembrolizumab monotherapy remains the first-line standard of care for patients with metastatic NSCLC and a PD-L1 tumor propo...
We examined the expression of Programmed Death Ligand 1 (PD-L1) and defined the tumor immune microenvironment ... P Koirala,ME Roth,J Gill,... - 《Sci Rep》 被引量: 30发表: 2016年 Increased PD-L1 and T-cell infiltration in the presence of HLA class I expression in metastatic high-...
the molecular mechanisms that may be responsible for the poor prognosis of these tumors, revealed that FGF-2 expression correlates positively with the expression of epithelial to mesenchymal transition (EMT)-promoting transcription factors and with changes in gene expression that are characteristic of ...
As PD-L1 expression is a continuous biomarker that correlates with immunotherapy efficacy in NSCLC [1., 2., 3.], we hypothesized that among patients with NSCLC and a PD-L1 expression level of 50%–100%, those with the highest levels of PD-L1 expression would experience improved clinical ou...