参考文献: Vamsidhar Velcheti, et al., Five-Year Real-World Outcomes With Frontline Pembrolizumab Monotherapy in PD-L1 Expression ≥50% Advanced NSCLC, Clinical Lung Cancer (2024).
[4]Clinicopathological and prognostic significance of PD-L1 expression in colorectal cancer: a meta-analysis. Int J Colorectal Dis 2021 Jan;36(1) [5]A meta-analysis of CD274 (PD-L1) assessment and prognosis in colorectal cancer and its role in predicting response to anti-PD-1 therapy. Crit...
参考文献: Naffrichoux J, Poupin P, Pouillot W, et al. PD-L1 expression and its prognostic value in metastatic papillary renal cell carcinoma: Results from a GETUG multicenter retrospective cohort. Eur J Cancer. 2024;205:114121. doi:10.1016/j.ejca.2024.114121...
2、作者描述了PD-L1的各种翻译后修饰的作用,包括磷酸化、糖基化、乙酰化和泛素化。此外,还讨论了小分子药物调节这些机制的潜在用途。 中国医药大学校长洪明奇(Mien-Chie Hung)教授课题组在国际知名期刊Nat Rev Clin Oncol在线发表题为“Mechanisms regulating PD-L1 expression in cancers and associated opportunities ...
因此如果条件准许,可以适当使用一些助攻手段。 参考文献 Maggie Zhou, et al., Long-Term Remission with Ipilimumab/ Nivolumab in Two Patients with Different Soft Tissue Sarcoma Subtypes and No PD-L1 Expression,Case Rep Oncol 2021;14:459–465
参考文献:Hong G, Park HS, Yeo MK, Lee D, Chung C. Dynamic changes in pathology and PD-L1 expression in a patient with metastatic lung adenocarcinoma who received pembrolizumab therapy followed by two salvage surgeries two years later: A case report. Thorac Cancer. 2023 Aug;14(23):2320-232...
Meshulami N, Tavolacci S, de Miguel-Perez D, Rolfo C, Mack PC, Hirsch FR. Predictive Capability of PD-L1 Protein Expression for Patients With Advanced NSCLC: Any Differences Based on Histology? Clin Lung Cancer. 2023 Jul;24(5):401-406. doi: 10.1016/j.cllc.2023.03.014. Epub 2023 Apr...
4.Vanhersecke, L. et al. Mature tertiary lymphoid structures predict immune checkpoint inhibitor efficacy in solid tumors independently of PD-L1 expression. Nature Caner 2, 794–802 (2021). “阔然生物医药科技(上海)有限...
Yang Q, et al. Novel Biomarkers of Dynamic Blood PD-L1 Expression for Immune Checkpoint Inhibitors in Advanced Non-Small-Cell Lung Cancer Patients. Front Immunol. 2021 Apr 16; 12: 665133. 审批号:MI-PD1-1622-CN 免责声明: 本资讯由默沙东医学团队编辑提供,旨在用于医学专业人士间的学术交流,请勿随...
2023年3月9日，中山大学肿瘤防治中心康铁邦（中国细胞生物学学会肿瘤细胞生物学分会副会长）/武远众团队在Nature Cancer发表了题为Disrupting the phase separation of KAT8–IRF1 diminishes PD-L1 expression and promotes antitumor immunity的研究成果。该研究揭示了KAT8-IRF1凝聚体促进肿瘤细胞PD-L1表达，开发的特异...