PD-L1 expression was decreased in the samples from patients with AML with complete remission compared to that in patients with relapsed or refractory AML. In AML cell lines, glycolysis-associated genes ALDOA, PGK1, LDHA and HK2 were highly expressed in a PD-L1 high-expressed cell line. ...
Consistency Analysis of Programmed Death-Ligand 1 Expression between Primary and Metastatic Non-Small Cell Lung Cancer: A Retrospective Study. J Cancer. 2020 Jan 1;11(4):974-982. doi: 10.7150/jca.34793. PMID: 31949500; PMCID: PMC6959024. [20] The clinicopathological and prognostic significance ...
PD-L1 expression in non-small cell lung cancer: evaluation of the diagnostic accuracy of a laboratory-developed test using clone E1L3N in comparison with 22C3 and SP263 assays. Hum Pathol. 2019;90:54-59. doi:10.1016/j.humpath.2019.05.003 [10] Zhang W, Cao Z, Gao C, et al. High ...
even though other cells still express high levels of PD-L1. Specifically, cDC1s, which are particularly important for the priming and activation of CD8+T cells, upregulate PD-L1 expression upon antigen uptake. Consistent with a recent study, we found that PD-L1 on DCs protects them from kill...
but IFNGR1 expression was relatively low or absent compared to IFNGR2 (Supplementary Fig.S1B). Among these, AGS and SNU-719 cell lines that showed high PD-L1 expression levels were selected for further experiments. IFNγ induces higher PD-L1 expression in EBV (+) GC compared to EBV (−...
PD-1 expression is upregulated in activated T cells and remains high in exhausted T cells from tumor-infiltrating lymphocytes (Ahmadzadeh et al., 2009). Constitutive PD-L1 expression caused by aberrant transactivation due to genetic or signaling alteration in an intrinsic manner defines the innate...
Tissue-based PD-L1 expression, more than any variable other than microsatellite instability-high, identified varying degrees of benefit from ICI-containing therapy vs SOC among patients with aGEC in 17 RCTs. 在17项随机对照试验中,基于组织的 PD-L1 表达比除微卫星不稳定性高以外的任何变量都更能确定...
and accurate and reliable PD-L1 testing is crucial for screening potential beneficiaries of immunotherapy. This study aimed to investigate the expression of PD-L1 in patients with esophageal squamous cell carcinoma (ESCC) ...
FDA approves cemiplimab-rwlc for non-small cell lung cancer with high PD-L1 expression FDA批准西米普利单抗用于高PD-L1表达的非小细胞肺癌 ◆【1】On February 22, 2021, the Food and Drug Administration approved cemiplim...
High PD-L1 expression was significantly associated with response to pembrolizumab in patients with biliary tract cancer, a finding in line with previous studies on other tumors such as lung cancer11. To the best of our knowledge, this is the first study reporting correlation between PD-L1 ...