但当前尚不清楚ALK阳性NSCLC中PD-L1表达情况对ALK-TKI疗效的影响[1]。2024年美国临床肿瘤学会(ASCO)大会上公布的题为“High PD-L1 expression among patients with ALK rearranged non-small cell lungcancer and response to first line ALK ...
PD-L1 expression was decreased in the samples from patients with AML with complete remission compared to that in patients with relapsed or refractory AML. In AML cell lines, glycolysis-associated genes ALDOA, PGK1, LDHA and HK2 were highly expressed in a PD-L1 high-expressed cell line. ...
4 Hayato Kawachi, Motohiro Tamiya, Akihiro Tamiya, et al. Association between metastatic sites and first-line pembrolizumab treatment outcome for advanced non–small cell lung cancer with high PD-L1 expression: a retrospective multicenter cohort study[J]. Investigational New Drugs, https://doi.org/...
[13] Reck M, Remon J, Hellmann MD. First-Line Immunotherapy for Non-Small-Cell Lung Cancer[J]. J Clin Oncol, 2022, 40(6):586-597. [14] Kitano A, Ono M, Yoshida M, et al. Tumour-infiltrating lymphocytes a...
1、E.J. Aguilar et al. Outcomes to first-line pembrolizumab in patients with non-small-cell lung cancer and very high PD-L1 expression. https://www.annalsofoncology.org/article/S0923-7534(19)60984-1/fulltext 2、Takayuki Shiroyama et al. Pretreatment advanced lung cancer inflammation index ...
but IFNGR1 expression was relatively low or absent compared to IFNGR2 (Supplementary Fig.S1B). Among these, AGS and SNU-719 cell lines that showed high PD-L1 expression levels were selected for further experiments. IFNγ induces higher PD-L1 expression in EBV (+) GC compared to EBV (−...
cell-mediated immune response. The interaction of PD-1 with its main ligand, PD-L1, activates signaling pathways which inhibit T cell function, which is normally important to avoid excessive immune activation and autoimmunity [1]. However, high PD-L1 expression in tumor cells can allow them to...
[10] Zhang W, Cao Z, Gao C, et al. High concordance of programmed death-ligand 1 expression with immunohistochemistry detection between antibody clones 22C3 and E1L3N in non-small cell lung cancer biopsy samples. Transl Cancer Res. 2020;9(10):5819-5828. doi:10.21037/tcr-20-101 ...
Factors within the tumor microenvironment can induce high expression of the inhibitory receptor PD-1 on functional T cells. However, there is limited understanding of the degradation mechanism of PD-1. FBXO38 is recognized as the E3 ligase responsible for PD-1, directly targeting the PD-1 cytop...
U87 cells were stained for PD-L1, and PD-L1 expression (green) was examined on the membrane and cytoplasm using the structural protein vimentin (red), and the nucleus using DAPI (blue). Images suggests PD-L1 is expressed throughout the cell, with high expression seen in the nucleus. (G...