[6] Perol, M., E. Felip, U. Dafni, et al., Effectiveness of PD-(L)1 inhibitors alone or in combination with platinum-doublet chemotherapy in first-line (1L) non-squamous non-small-cell lung cancer (Nsq-NSCL...
PD-L1 expression was decreased in the samples from patients with AML with complete remission compared to that in patients with relapsed or refractory AML. In AML cell lines, glycolysis-associated genes ALDOA, PGK1, LDHA and HK2 were highly expressed in a PD-L1 high-expressed cell line. ...
Effectiveness of PD-(L)1 inhibitors alone or in combination with platinum-doublet chmotherapy in first-line (1L) non-squamous non-small-cell lung cancer (Nsq-NSCLC) with PD-L1-high expression using real-world data. Ann Oncol. 2022 May;33(5):511-521....
英文摘要: OBJECTIVE:To ev aluate the economics of pembrolizumab versus first-line chemotherapy in the treatment of advanced non-small cell lung cancer with high programmed cell death protein ligand 1(PD-L1)expression from the perspective of Chinese healthcare system. METHODS :Published KEYNOTE- 042...
而依据引起肿瘤细胞PD-L1表达的分子机制,可将PD-L1表达分为组成型PD-L1表达(constitutive PD-L1 expression)和诱导型PD-L1表达(inducible PD-L1 expression)。前者一般由肿瘤相关基因的变异所致,表现为肿瘤细胞PD-L1表达呈均一分布,与免疫治疗疗效相关性不...
程序性死亡配体-1(pd-l1)表达的成像与靶向1.联邦政府资助的研究或开发2.本发明根据由美国国立卫生研究院(nationalinstituteofhealth)授予的ca236616和ca166131在政府支持下进行。政府在本发明中拥有某些权利。3.背景4.尽管免疫检查点疗法(ict)在广泛的癌症中的有效应用,但仅患有晚期癌症的患者子集经历了显著的临床...
PD-L1 was exclusively expressed on either TC or IC. Transcriptome analysis demonstrated that IC3 expressed higher levels of the effector T cell markers than TC3, suggesting that PD-L1 expression is regulated via an adaptive IFNγ-mediated mechanism. High PD-L1 expression on IC, but not TC, ...
(Fig.3a, b). In MC38 tumor-bearing mice, cDC1 significantly upregulated PD-L1 in dLNs (Fig.3band Supplementary Fig.3d). In addition, cDC1 in tumor microenvironment has the highest change in PD-L1 expression. By contrast, most cDC2 expressed a high level of PD-L1, which was further ...
PD-1/PD-L1相互作用作为非小细胞肺癌患者分层的预测性生物标志物,结合PD-L1表达,可以显著提高对免疫治疗的反应率。 SCI 12 March 2023 Functional Engagement of the PD-1/PD-L1 Complex But Not PD-L1 Expression Is Highly Predictive of Patient Response to Immunotherapy in Non–Small-Cell Lung Cancer ...
expression in non‐small cell lung cancer[J]. Mod Pathol, 2017, 30(3):340‐349. [5] Varga A , Piha-Paul S A , Ott P A , et al. Pembrolizumab in patients (pts) with PD-L1–positive (PD-L1 + ) advanced ovarian cancer: Updated ...