表达(Expression) Naive T细胞在TCR信号通路激活的时候,会飞快地表达PD-1。而当T细胞被连续不断地刺激时,T细胞会变成exhausted T,会持续性地表达很高的PD-1。 除了在CD4, CD8 T细胞上有表达,PD-1在Treg, B, NK, NKT细胞也有表达。 目前已知的PD-1的ligand有两个: PD-L1 (CD274) PD-L2 (CD273) 和PD-...
2024年1月,Cell上发文题为“SMARCAL1 is a dual regulator of innate immune signaling and PD-L1 expression that promotes tumor immune evasion”的文章,在本研究中,发现DDR因子SMARCAL1通过两种互补的机制促进了癌症免疫逃避。具体而言,SMARCAL1缺陷引发了癌症自主的免疫信号,同时尽管来自先天免疫应答的IFN信号,但...
近日,来自美国哥伦比亚大学的Alberto Ciccia研究小组在Cell杂志上发表题为SMARCAL1 is a dual regulator of innate immune signaling and PD-L1 expression that promotes tumor immune evasion的研究论文,这篇文章发现DNA易位酶SMARCAL1通过两种不...
2024年8月8日,Cell杂志背靠背在线发表美国匹兹堡大学医学院Dario A.A. Vignali研究团队题为LAG-3 and PD-1 synergize on CD8+T cells to drive T cell exhaustion and hinder autocrine IFN-γ-dependent anti-tumor immunity和Bl...
cell subset while CD4+PD-1highT cells had negligible expression of TIM-3 (Figure 4b). Approximately 40% of CD4+PD-1lowT cells expressed TIM-3. Furthermore, we observed that the intratumoral CD8+T-cell subset that were PD-1low, also expressed high levels of TIM-3 on their surface, ...
PD-1 expression on peripheral blood cells increases with stage in renal cell carcinoma patients and is rapidly reduced after surgical tumor resection. Cancer... A.,W.,MacFarlane,... - 《Cancer Immunology Research》 被引量: 62发表: 2013年 Lower expression levels of the programmed death 1 recep...
第三篇论文题为:LAG-3 sustains TOX expression and regulates the CD94/NKG2-Qa-1b axis to govern exhausted CD8 T cell NK receptor expression and cytotoxicity(LAG-3维持TOX表达并调节CD94/NKG2-Qa-1b轴,从而调控耗竭的CD8 T细胞的NK受体表达和细胞毒性)。
Marry（化名）是一位66岁的美国女性，患有肺腺癌[1]。虽然她的肺癌在放化疗后一度完全缓解，但在13个月后她的肿瘤复发了。幸运的是，活检显示她的肿瘤PD-L1阳性率高达100%，正好可以使用PD-1抑制剂治疗。不过Marry在第2次使用PD-1单抗后，病情急转直下，疲劳、恶心、呼吸急促，胸腔里出现大量癌性胸水，还发生...
Using flow cytometry, the expression of PD-1 was determined on CD8+ T lymphocytes and CD4+ T lymphocytes. ELISA was used to determine the levels of IL-10 in the serum. We found a remarkable decrease in T cell counts with functionally exhausted surviving T cells in the patient groups, ...
近日,日本国立癌症研究中心Hiroyoshi Nishikawa教授领衔在Cancer Cell杂志发表了题为Lactic acid promotes PD-1 expression in regulatory T cells in highly glycolytic tumor microenvironments的研究长文,通过从代谢角度研究TME中表达PD-1的效应T细胞和Treg细胞间稳态平衡的影响因素,发现乳酸能够作为Treg细胞的代谢检查点并...