表达(Expression) Naive T细胞在TCR信号通路激活的时候,会飞快地表达PD-1。而当T细胞被连续不断地刺激时,T细胞会变成exhausted T,会持续性地表达很高的PD-1。 除了在CD4, CD8 T细胞上有表达,PD-1在Treg, B, NK, NKT细胞也有表达。 目前已知的PD-1的ligand有两个: PD-L1 (CD274) PD-L2 (CD273) 和PD-...
近日，暨南大学附属第一医院/基础医学与公共卫生学院李扬秋研究员团队刘思阳博士后与广东省人民医院吴一龙教授团队合作，在《Science Bulletin》上发表了题为“PD-L1 expression guidance on sintilimab versus pembrolizumab with or without platinum-doublet chemotherapy in untreated patients with advanced non-small cell...
2024年1月,Cell上发文题为“SMARCAL1 is a dual regulator of innate immune signaling and PD-L1 expression that promotes tumor immune evasion”的文章,在本研究中,发现DDR因子SMARCAL1通过两种互补的机制促进了癌症免疫逃避。具体而言,SMARCAL1缺陷引发了癌症自主的免疫信号,同时尽管来自先天免疫应答的IFN信号,但...
近日,来自美国哥伦比亚大学的Alberto Ciccia研究小组在Cell杂志上发表题为SMARCAL1 is a dual regulator of innate immune signaling and PD-L1 expression that promotes tumor immune evasion的研究论文,这篇文章发现DNA易位酶SMARCAL1通过两种不...
2022年1月27日，日本国立癌症研究中心Hiroyoshi Nishikawa教授领衔在Cancer Cell杂志发表了题为Lactic acid promotes PD-1 expression in regulatory T cells in highly glycolytic tumor microenvironments的研究长文，通过从代谢角度研究TME中表达PD-1的效应T细胞和Treg细胞间稳态平衡的影响因素，发现乳酸能够作为Treg细胞的...
[6] Wang X, Teng F, Kong L, et al. PD-L1 expression in human cancers and its association with clinical outcomes[J/OL]. Onco Targets Ther, 2016, 9: 5023-5039[2023-02-02]. https://www.dovepress.com/pd-l1...
[1] Maggie Liu SY, Huang J, Deng JY,et al. PD-L1 expression guidance on sintilimab versus pembrolizumab with or without platinum-doublet chemotherapy in untreated patients with advanced non-small cell lung cancer (CTONG1901): A phase 2, randomized, controlled trial. Sci Bull (Beijing). 20...
近日,日本国立癌症研究中心Hiroyoshi Nishikawa教授领衔在Cancer Cell杂志发表了题为Lactic acid promotes PD-1 expression in regulatory T cells in highly glycolytic tumor microenvironments的研究长文,通过从代谢角度研究TME中表达PD-1的效应T细胞和Treg细胞间稳态平衡的影响因素,发现乳酸能够作为Treg细胞的代谢检查点并...
“PD-L1 expression guidance on sintilimab versus pembrolizumab with or without platinum-doublet chemotherapy in untreated patients with advanced non-small cell lung cancer (CTONG1901): a phase 2, randomized, controlled trial”的临床试验结果文章,公布了首个直接对比两种PD-1抑制剂的前瞻性研究的数据...
[7] Y Ishida et al., (1992), Induced expression of PD-1, a novel member of the immunoglobulin gene superfamily, upon programmed cell death, EMBO Journal, vol. 11 pg. 3887 [8] CRI Names Winners of Top Scientific Prize, Retrieved August 26, 2018, from https://www.cancerresearch.org/...