为了明了上述表型的机制,研究者对脾脏NK进行RNA测序,发现下调显著的基因有敲除的GR(Nr3c1),糖皮质激素诱导蛋白GILZ(Tsc22d3)和PD1(Pdcd1)。 研究者重点关注了明星分子PD1,FACS结果发现感染MCMV后WT小鼠脾脏NK细胞PD1表达上升,GR敲除抑制PD1的表达上调(图4)。 图4 感染MCMV后脾脏NK细胞GR依赖的PD1表达 糖皮质激素...
However, on T cells, the expression of both TIGIT and PD-1 peaked during early pregnancy, and then declined gradually thereafter. Moreover, the expressions of granzyme B, IFN-纬 and CD107a by pNK cells also decreased over the course of pregnancy. Compared with TIGIT- NK cells, TIGIT + ...
[3]Hsu J, et al. Contribution of NK cells to immunotherapy mediated by PD-1/PD-L1 blockade. J Clin Invest. 2018 Oct 1;128(10):4654-4668. doi: 10.1172/JCI99317. Epub 2018 Sep 10. PMID: 30198904; PMCID: PMC6159991. [4]S. J. Judge, et al, Minimal PD-1 expression in mouse a...
[3]Hsu J, et al. Contribution of NK cells to immunotherapy mediated by PD-1/PD-L1 blockade. J Clin Invest. 2018 Oct 1;128(10):4654-4668. doi: 10.1172/JCI99317. Epub 2018 Sep 10. PMID: 30198904; PMCID: PMC6159991. [4]S. J. Judge, et al, Minimal PD-1 expression in mouse a...
PD-1在活化的T细胞和B细胞、自然杀伤(NK)细胞、单核细胞、树突状细胞和癌细胞如黑色素瘤上表达。PD-1通过与PD-L1结合而被激活,并且与PD-L2具有更高的亲和力。两者的表达都是干扰素/细胞因子诱导的,但具有特定的表达模式:PD-L1在造血细胞和非造血细胞中广泛表达,而PD-L2主要在APC上表达。
1.PD-1 expression by tumour-associated macrophages inhibits phagocytosis and tumour immunity 2.The mechanism of anti-PD-L1 antibody efficacy against PD-L1 negative tumors identifies NK cells expressing PD-L1 as a cytolytic effector 3.PD-L1...
SatoH, NiimiA, YasuharaT, et al.DNA double-strand break repair pathway regulates PD-L1 expression in cancer cells[J].Nat Commun, 2017, 8(1): 1751.DOI: 10.1038/s41467-017-01883-9. CoelhoMA, de Carné TrécessonS, RanaS, et al.Oncogenic RAS signaling promotes tumor immunoresistance by...
[3]Hsu J, et al. Contribution of NK cells to immunotherapy mediated by PD-1/PD-L1 blockade. J Clin Invest. 2018 Oct 1;128(10):4654-4668. doi: 10.1172/JCI99317. Epub 2018 Sep 10. PMID: 30198904; PMCID: P...
PD-1 NK cells have been detected in high percentage in peripheral blood and ascitic fluid of ovarian carcinoma patients. To acquire information on PD-1 expression and physiology in human NK cells, we analyzed whether PD-1 mRNA and protein are present in resting, surface PD-1, NK cells ...
“Distinct antibody clones detect PD-1 checkpoint expression and block PD-L1 interactions on live murine melanoma cells”, it was shown that the anti-PD-1 29F.1A12 monoclonal antibody(抗PD-1 29F.1A12单克隆抗体) recognizes the PD-1 surface protein on live B16-F10 melanoma cells, live YUM...