2024年1月,Cell上发文题为“SMARCAL1 is a dual regulator of innate immune signaling and PD-L1 expression that promotes tumor immune evasion”的文章,在本研究中,发现DDR因子SMARCAL1通过两种互补的机制促进了癌症免疫逃避。具体而言,SMARCAL1缺陷引发了癌症自主的免疫信号,同时尽管来自先天免疫应答的IFN信号,但...
PD-L1 expression by dendritic cells is a key regulator of T-cell immunity in cancer,Nat Cancer. 2020。巨噬细胞是小鼠和人类肿瘤PD-L1主要来源。 研究者在MC38小鼠肿瘤模型中,表征了PD-L1和B7-1在肿瘤浸髓系细胞群体中的表达。CD11b+CD64+巨噬细胞为主,(约占75%),其数量远远超过DC细胞(约2%)。 ...
近日,来自美国哥伦比亚大学的Alberto Ciccia研究小组在Cell杂志上发表题为SMARCAL1 is a dual regulator of innate immune signaling and PD-L1 expression that promotes tumor immune evasion的研究论文,这篇文章发现DNA易位酶SMARCAL1通过两种不...
It has been shown that signaling through PD-1 has a critical role in T-cell-mediated immune responses in a variety of pathophysiological conditions. To determine the role of PD-1 in FL, we first measured its expression in biopsy lymph nodes of FL patients. By immunohistochemistry, we observed...
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PD-L1表达是目前研究最多且证据较充分的疗效预测标志物。最近发表在Cells杂志(IF=4.366)的一篇综述“Tumour PD-L1 Expression in Small-Cell Lung Cancer: A SystematicReview and Meta-Analysis”首次对SCLC中PD-L1的表达进行了全面的荟萃分析。 研...
Expression of the PD-1 antigen on the surface of stimulated mouse T and B lymphocytes. Int. Immunol. 8, 765–772 (1996) Article CAS Google Scholar Benson, D. M. Jr et al. The PD-1/PD-L1 axis modulates the natural killer cell versus multiple myeloma effect: a therapeutic target for...
Programmed cell death marker-1(PD-1) expression, a critical checkpoint for T cell exhaustion, can be modulated by interleukin-10, which also mediates apoptotic T cell cytopenia. We aimed to measure the level of PD-1 expression and to investigate its correlation with IL-10 serum levels in ...
近日,日本国立癌症研究中心Hiroyoshi Nishikawa教授领衔在Cancer Cell杂志发表了题为Lactic acid promotes PD-1 expression in regulatory T cells in highly glycolytic tumor microenvironments的研究长文,通过从代谢角度研究TME中表达PD-1的效应T细胞和Treg细胞间稳态平衡的影响因素,发现乳酸能够作为Treg细胞的代谢检查点并...