参考文献: [1]Ping,Yu et al.PD-1 signaling limits expression of phospholipid phosphatase 1 and promotes intratumoral CD8+T cell ferroptosis.Immunity.
近日,郑州大学生物细胞治疗中心张毅教授研究团队在Immunity上发表了题为“PD-1 signaling limits expression of phospholipid phosphatase 1 and promotes intratumoral CD8+ T cell ferroptosis ”的文章,对肿瘤浸润CD8+T细胞的磷脂代谢进行了详细解析和探究,为未来提高T细胞相关的免疫治疗疗效奠定了理论基础。该研究中的单...
磷脂磷酸酶1(PLPP1)是一种调控磷脂代谢的关键酶,那在TME中PD-1与 PLPP1的表达是否相关,PLPP1能否调控磷脂代谢来损害CD8+ T细胞的功能,都值得深入探究。 本月,由郑州大学第一附属医院张毅教授带领的研究团队在《Immunity》杂志上发表了题为“PD-1 signaling limits expression of phospholipid phosphatase 1 and p...
Wu, D., Hu, L., Han, M.et al.PD-1 signaling facilitates activation of lymphoid tissue inducer cells by restraining fatty acid oxidation.Nat Metab4, 867–882 (2022). https://doi.org/10.1038/s42255-022-00595-9 Download citation
少数研究发现PD-1抑制剂会使记忆性T细胞减少【7】。因此，PD-1如何影响记忆CD8 T 细胞值得深入研究。2021年10月13日，华盛顿大学医学院的Surojit Sarkar团队的Vandana Kalia（第一作者）在Science Translational Medicine上发表了题为Metabolic regulation by PD-1 signaling promotes long-lived quiescent CD8 T cell ...
death 1 and its ligands in regulating autoimmunity and infection. NATURE IMMUNOLOGY. 2007, 8: 239-245.3. Hashem O A., et al. PD-1 and PD-L1 Checkpoint Signaling Inhibition for Cancer Immunotherapy: Mechanism, Combinations, and Clinical Outcome. Frontiers in Pharmacology. 2017, 8: 1-15.
3. Hashem O A., et al. PD-1 and PD-L1 Checkpoint Signaling Inhibition for Cancer Immunotherapy: Mechanism, Combinations, and Clinical Outcome. Frontiers in Pharmacology. 2017, 8: 1-15.
4.Wu, Q., Jiang, L., Li, Sc. et al. Small molecule inhibitors targeting the PD-1/PD-L1 signaling pathway. Acta Pharmacol Sin 42, 1–9 (2021). 5.Zak KM, Kitel R, Przetocka S, Golik P, Guzik K, Musielak B, et al. Structure ...
"These patients could be helped by medications that reverse the loss of PD-1 signaling and thereby destroy the tumor cells. This type of medication already exists for other forms of cancer - In our opinion, use with T cell Non-Hodgkin's lymphoma should also be considered," says Jürgen Rul...
这个问题,在昨天发表在《Cell》子刊上面的名为“Antigen-Presenting Cell-Intrinsic PD-1 Neutralizes PD-L1 in cis to Attenuate PD-1 Signaling in T Cells”为我们揭示了答案:原来肿瘤表达的PD-L1,是可以自己“消化”的! T细胞上面会表达...