近日，武汉大学研究人员在知名期刊《Cell Research》上发表了题为“PD-1 signaling negatively regulates the common cytokine receptor γ chain via MARCH5-mediated ubiquitination and degradation to suppress anti-tumor immunity”的研究论文，该研究中，研究人员发现PD-1连接导致BATF依赖的膜相关E3泛素连接酶MARCH5...
3. Wu Q, Jiang L, Li SC, et al. Small molecule inhibitors targeting the PD-1/PD-L1 signaling pathway. Acta Pharmacol Sin. 2021, 42(1): 1-9. doi: 10.1038/s41401-020-0366-x. 4. 中国抗癌协会肿瘤病理专业委员会,中国临床肿瘤...
2023年1月9日，中山大学大学赵萌和蒋琳加教授团队在Nature Cell Biology杂志在线发表题为PD-1 signaling defines and protects leukemic stem cells from T-cell-receptor-induced cell death in T-cell acute lymphoblastic leukemia的研究论文。该研究鉴定了PD-1分子是T-ALL白血病LSC的标记物，发现PD-1是保护LSC避免...
少数研究发现PD-1抑制剂会使记忆性T细胞减少【7】。因此，PD-1如何影响记忆CD8 T 细胞值得深入研究。2021年10月13日，华盛顿大学医学院的Surojit Sarkar团队的Vandana Kalia（第一作者）在Science Translational Medicine上发表了题为Metabolic regulation by PD-1 signaling promotes long-lived quiescent CD8 T cell m...
3.Immune Checkpoint Receptors Signaling in T Cells. Int J Mol Sci.2022 Apr; 23(7): 3529. 封面图来源:123rf 2023年1月1日至今,~20笔中国新药出海交易横空出世,总金额高达上百亿美元!一时间,喜讯频传,令行业、企业和每一位同药振奋!曾经提出“百靶竞技,百炼创新,百家上市,百...
death 1 and its ligands in regulating autoimmunity and infection. NATURE IMMUNOLOGY. 2007, 8: 239-245.3. Hashem O A., et al. PD-1 and PD-L1 Checkpoint Signaling Inhibition for Cancer Immunotherapy: Mechanism, Combinations, and Clinical Outcome. Frontiers in Pharmacology. 2017, 8: 1-15.
本月,由郑州大学第一附属医院张毅教授带领的研究团队在《Immunity》杂志上发表了题为“PD-1 signaling limits expression of phospholipid phosphatase 1 and promotes intratumoral CD8+ T cell ferroptosis”的研究论文,为我们解答了以上疑问,揭开了PD-1信号如何削弱CD8+ T细胞的神秘面纱。主要研究结果:一.PLPP1 在瘤...
Our screen confirmed known regulators in proximal PD-1 signaling and, importantly, identified an additional 1112 unique genes related to PD-1 ability to inhibit T cell functions. These genes were strongly associated with the response of cancer patients to PD-1 blockades ...
[4] Wu Q, Jiang L, Li SC, et al. Small molecule inhibitors targeting the PD-1/PD-L1 signaling pathway. Acta Pharmacol Sin. 2021, 42(1): 1-9. doi: 10.1038/s41401-020-0366-x. [5] Lin KX, Istl AC, Quan D, et al. PD-1 and ...
4.Wu, Q., Jiang, L., Li, Sc. et al. Small molecule inhibitors targeting the PD-1/PD-L1 signaling pathway. Acta Pharmacol Sin 42, 1–9 (2021). 5.Zak KM, Kitel R, Przetocka S, Golik P, Guzik K, Musielak B, et al. Structure ...