Phenotypic and transcriptional profiling of regulatory T (Treg) cells at homeostasis reveals that T cell receptor activation promotes Treg cells with an effector phenotype (eTreg) characterized by the production of interleukin-10 and expression of the inhibitory receptor PD-1. At homeostasis, blockade...
The PD-1/PDL-1 immune checkpoint inhibitors revolutionized cancer treatment, yet osteosarcoma remains a therapeutic challenge. In some types of cancer, PD-1 receptor is not solely expressed by immune cells but also by cancer cells, acting either as a tumor suppressor or promoter. While well-char...
W. Programmed cell death ligand 1 (PD-L1) signaling regulates macrophage proliferation and activation. Cancer Immunol. Res. 6, 1260–1273 (2018). Article CAS PubMed Google Scholar Hudson, K., Cross, N., Jordan-Mahy, N. & Leyland, R. The extrinsic and intrinsic roles of PD-L1 and ...
Tumor interferon signaling regulates a Multigenic resistance program to immune checkpoint Blockade. Cell. 2016;167(6):1540–e15541512. Article PubMed PubMed Central CAS Google Scholar Kim JM, Chen DS. Immune escape to PD-L1/PD-1 Blockade: seven steps to success (or failure). Ann Oncol. ...
Cognitive and functional declines were associated with diminished CD8+ T-cells and status changes in CD25 (IL-2RA) and PD-1. A Following the flow cytometric analysis, the PD-1+/PD-L1+ T-cell subset amounts were correlated with MMSE-minus and CDR-SOB to investigate the relationship between...
Moreover, inhibition of NF-κB signaling by knocking down the expression of p65 decreased the levels of PD-L1 proteins in NCI-N87 and AGS cells treated by chloroquine or 3-MA (Fig. 4c and Additional file 1: Figure S4D). These results indicated that autophagy inhibitors upregulated the ...
Abbreviations: PD-L1, programmed death-ligand 1; P-score, proportion score. *P<0.05. aThe percentage of positive staining area by immunohistochemistry of CD8 within the tumor is shown as median plus/minus s.d. Clinicopathological Significance of PD-L1 Expression in EBV-Negative GC The expression...
To improve anti-cancer therapy, it is critical to reveal the mechanisms by which PD-1 regulates T cell responses. We performed global quantitative phosphoproteomic interrogation of PD-1 signaling in T cells. By complementing our analysis with functional validation assays, we show that PD-1 targets...
PDLIM1 negatively regulates NF-κB signaling. Since PDLIM2 negatively regulates TLR-mediated NF-κ B signaling, we next examined the effect of PDLIM1 on TLR-induced, NF-κ B-mediated gene activation in a reporter assay. Mouse embryonic fibroblasts (MEF) were transfected with a ...
antibodies are only able to recruit pairs of monomeric receptors, such as PD-1, leading to much less intense signaling. (FIG. 11C) By using antibodies that bind to two non-overlapping epitopes, higher densities of monomeric signaling receptors can be generated, giving much more potent signaling...