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参考资料: Ai L, Xu A, Xu J. Roles of PD-1/PD-L1 Pathway: Signaling, Cancer, and Beyond.Adv Exp Med Biol. 2020;1248:33-59. doi:10.1007/978-981-15-3266-5_3 Han Y, Liu D, Li L. PD-1/PD-L1 pathway: current researches in cancer.Am J Cancer Res. 2020;10(3):727-742. Pu...
3.田季平, 张剑, 周金培,等. 免疫检查点PD-1/PD-L1小分子抑制剂的研究进展[J]. 中国药科大学学报, 2019. 4.Wu, Q., Jiang, L., Li, Sc. et al. Small molecule inhibitors targeting the PD-1/PD-L1 signaling pathway. Acta Pharmacol Sin 42, 1...
3.田季平, 张剑, 周金培,等. 免疫检查点PD-1/PD-L1小分子抑制剂的研究进展[J]. 中国药科大学学报, 2019. 4.Wu, Q., Jiang, L., Li, Sc. et al. Small molecule inhibitors targeting the PD-1/PD-L1 signaling pathway. Acta Pharmacol Sin 42, 1–9 (2021). 5.Zak KM, Kitel R, Przetoc...
In this review, firstly, we focus on the immunosuppressive mechanism of sepsis and the structure and function of the PD-1 signaling pathway. The variety of the PD-1 signaling pathways in sepsis is introduced. Then, the relationship between the PD-1 signaling pathway and immune cells and organ...
Figure 1. The signaling pathway of PD-1/PD-L1 3. PD-1/PD-L1与肿瘤免疫治疗 肿瘤免疫治疗就是通过重新启动并维持肿瘤-免疫循环,恢复机体正常的抗肿瘤免疫反应,从而控制与清除肿瘤的一种治疗方法。包括单克隆抗体类免疫检查点抑制剂、治疗性抗体、癌症疫苗、细胞治疗和小分子抑制剂等。
Iwai Y, Hamanishi J, Chamoto K, Honjo T. Cancer immunotherapies targeting the PD-1 signaling pathway. J Biomed Sci. 2017;24(1):26. doi:10.1186/s12929-017-0329-9. PMID:28376884Iwai Y,Hamanishi J,Chamoto K,et al.Cancer immunotherapies targeting the PD-1signaling pathway[J].J Biomed ...
[13].Qian Wu, Li Jiang, Si-Cheng Li, et al. Small molecule inhibitors targeting the PD-1/PD-L1 signaling pathway. Acta Pharmacol Sin. 2021 Jan;42(1):1-9. [14].Julia A Beaver, Richard Pazdur. The Wild West of Chec...
少数研究发现PD-1抑制剂会使记忆性T细胞减少【7】。因此，PD-1如何影响记忆CD8 T 细胞值得深入研究。2021年10月13日，华盛顿大学医学院的Surojit Sarkar团队的Vandana Kalia（第一作者）在Science Translational Medicine上发表了题为Metabolic regulation by PD-1 signaling promotes long-lived quiescent CD8 T cell ...
[3] Wu, Qian et al. “Small molecule inhibitors targeting the PD-1/PD-L1 signaling pathway.” Acta pharmacologica Sinica, 10.1038/s41401-020-0366-x [4] Fattakhova, Elena et al. “Identification of the FDA-Approved Drug Pyrvinium as a Small-Molecule Inhibitor of the PD-1/PD-L1 Interacti...