Bardhan K,Anagnostou T,Boussiotis VA. The PD1: PD-L1 /2 pathway from discovery to clinical implementation[J].Front Immunol,2016,7( 1) : 550. Rota G,Niogret C,Dang AT,et al. Shp-2 is dispensable for establishing T cell exhaustion and for PD-1 signaling in vivo[J].Cell Rep,2018,2...
Figure 1. The signaling pathway of PD-1/PD-L1 3. PD-1/PD-L1与肿瘤免疫治疗 肿瘤免疫治疗就是通过重新启动并维持肿瘤-免疫循环,恢复机体正常的抗肿瘤免疫反应,从而控制与清除肿瘤的一种治疗方法。包括单克隆抗体类免疫检查点抑制剂、治疗性抗体、癌症疫苗、细胞治疗和小分子抑制剂等。 近几年,肿瘤免疫治疗的...
图1. PD-1/PD-L1信号通路 参考文献 1. Francisco L M., et al. The PD-1 pathway in tolerance and autoimmunity. Immunological Reviews.2010, 236: 219–42.2. Arlene H S., et al. The function of programmed cell death 1 and its ligands in regulating autoimmunity and infection. NATURE IMMUNO...
Woods等[1]发现组蛋白去乙酰化酶(histone deacetylases，HDAC)抑制剂处理黑色素瘤细胞系可以导致PD-L1基因上游组蛋白乙酰化水平上调，增强PD-L1的表达，同时HDAC抑制剂还可以增强PD-1检查点阻断药物的疗效，因此联合应用HDAC抑制剂和抗PD-1药物可能是一种新的协同治疗策略。溴结构域和超末端结构域(bromodomain and ex...
Iwai Y, Hamanishi J, Chamoto K, Honjo T. Cancer immunotherapies targeting the PD-1 signaling pathway. J Biomed Sci 2017;24:26.Iwai, Y.; Hamanishi, J.; Chamoto, K.; Honjo, T. Cancer immunotherapies targeting the PD-1 signaling pathway. J. Biomed. Sci. 2017, 24, 26. [CrossRef] ...
目的探讨多囊卵巢综合征(polycystic ovary syndrome,PCOS)患者外周血程序性细胞死亡蛋白1(programmed cell death protein 1,PD-1)和其配体PD-L1 表达水平与细胞因子相关性。 方法利用GEO数据库中GSE54248数据集筛选出PCOS中差异表达PD-1...
少数研究发现PD-1抑制剂会使记忆性T细胞减少【7】。因此，PD-1如何影响记忆CD8 T 细胞值得深入研究。2021年10月13日，华盛顿大学医学院的Surojit Sarkar团队的Vandana Kalia（第一作者）在Science Translational Medicine上发表了题为Metabolic regulation by PD-1 signaling promotes long-lived quiescent CD8 T cell ...
程序化死亡配体-1(PD-L1)靶向免疫治疗被广泛应用于不同类型的癌症中,患者从PD-L1靶向免疫治疗的获益主要依赖于肿瘤组织PD-L1的表达水平。本文综述了靶向PD-L1的核医学分子影像探针,并讨论其在肿瘤PD-L1显像中的应用。
Among this class of immune checkpoints, PD-1/PD-L1 was recognized as an anticancer drug target for many years, and so far, several monoclonal antibodies have achieved encouraging outcome in cancer treatment by targeting the PD-1/PD-L1 signaling pathway. Due to the inherent limitations of ...
图1.PD-1/PD-L1信号通路 参考文献 1. Francisco L M., et al. The PD-1 pathway in tolerance and autoimmunity. Immunological Reviews.2010, 236: 219–42. 2. Arlene H S., et al. The function of programmed cell death 1 and its ligands in regulating autoimmunity and infection. NATURE IMMUNO...