Bardhan K,Anagnostou T,Boussiotis VA. The PD1: PD-L1 /2 pathway from discovery to clinical implementation[J].Front Immunol,2016,7( 1) : 550. Rota G,Niogret C,Dang AT,et al. Shp-2 is dispensable for establishing T cell exhaustion and for PD-1 signaling in vivo[J].Cell Rep,2018,2...
In this review, firstly, we focus on the immunosuppressive mechanism of sepsis and the structure and function of the PD-1 signaling pathway. The variety of the PD-1 signaling pathways in sepsis is introduced. Then, the relationship between the PD-1 signaling pathway and immune cells and organ...
图1. PD-1/PD-L1信号通路 参考文献 1. Francisco L M., et al. The PD-1 pathway in tolerance and autoimmunity. Immunological Reviews.2010, 236: 219–42.2. Arlene H S., et al. The function of programmed cell death 1 and its ligands in regulating autoimmunity and infection. NATURE IMMUNO...
2022年1月7日,台北医科大学研究人员通过基于结构的虚拟筛选确定了能有效抑制PD-1/PD-L1相互作用的小分子抑制剂CH-4.7,CH-4.7 有效阻断了 PD-1/sPD-L1 相互作用,但维持了 Jurkat 细胞分泌IL-2和IFN-γ。CH-4.7 特异性靶向 PD-1 并维持 T 细胞活化。细胞毒性测试表明对 THP-1 和 Jurkat T 细胞系的影响...
除此之外,TargetMol还可提供多种 PD-1/PD-L1抑制剂、抗体,助力您的研究,欢迎 私信咨询~ 参考资料: Ai L, Xu A, Xu J. Roles of PD-1/PD-L1 Pathway: Signaling, Cancer, and Beyond.Adv Exp Med Biol. 2020;1248:33-59. doi:10.1007/978-981-15-3266-5_3 ...
1.Lin C , Chen X, Liu J, Huang Y, Ou-YangX. Advances of PD-1/PD-L1 signaling pathway in immune escape and treatment for non-small celllung cancer. Chinese Journal of Lung Cancer [01 Oct 2014,17(10):734-740. Doi:10.3779/j.issn.1009-3419.2014.10.05 ...
笔者个人较为看好共同阻断HPK1和PD-L1发挥出的增强抗肿瘤效应,期待国产HPK1抑制剂可以和国产PD-1/PD-L1小分子抑制剂联手,创出佳绩。 PD-1/PD-L1小分子抑制剂临床试验考量: 2、满足需求 定点突破 在兼顾安全性和有效性的前提下,小分子抑制剂...
少数研究发现PD-1抑制剂会使记忆性T细胞减少【7】。因此，PD-1如何影响记忆CD8 T 细胞值得深入研究。2021年10月13日，华盛顿大学医学院的Surojit Sarkar团队的Vandana Kalia（第一作者）在Science Translational Medicine上发表了题为Metabolic regulation by PD-1 signaling promotes long-lived quiescent CD8 T cell ...
正常生理状况下，PD-1/PD-L1抑制性共刺激信号的主要作用是防止T细胞不受控制地过度活化攻击正常细胞。不同类型肿瘤细胞表面表达高水平的PD-L1，这些过度表达的PD-L1通过PD-1/PD-L1信号途径诱导T细胞衰竭，使肿瘤细胞逃避T细胞免疫攻击，直接影响肿瘤患者的治疗效果及临床预后。PD-1/PD-L1通路阻断剂，包括PD-1单...
The PD-1/PD-L1 signaling pathway is crucial in dampening immunosurveillance for tumors. Tumors can escape host immune surveillance by expressing PD-L1, which negatively regulates immune responses by interacting with PD-1 on T cells (Fig. 1) [40]. Indeed, data from clinical samples indicate tha...