参考文献 1. Francisco L M., et al. The PD-1 pathway in tolerance and autoimmunity. Immunological Reviews.2010, 236: 219–42.2. Arlene H S., et al. The function of programmed cell death 1 and its ligands in regulating autoimmunity and infection. NATURE IMMUNOLOGY. 2007, 8: 239-245.3...
3.田季平, 张剑, 周金培,等. 免疫检查点PD-1/PD-L1小分子抑制剂的研究进展[J]. 中国药科大学学报, 2019. 4.Wu, Q., Jiang, L., Li, Sc. et al. Small molecule inhibitors targeting the PD-1/PD-L1 signaling pathway. Acta Pharmacol Sin 42, 1–9 (2021). 5.Zak KM, Kitel R, Przetoc...
1. Francisco L M., et al. The PD-1 pathway in tolerance and autoimmunity. Immunological Reviews.2010, 236: 219–42. 2. Arlene H S., et al. The function of programmed cell death 1 and its ligands in regulating autoimmunity and infection. NATURE IMMUNOLOGY. 2007, 8: 239-245. 3. Hash...
[3] Boussiotis V A. Molecular and Biochemical Aspects of the PD-1 Checkpoint Pathway[J]. New England Journal of Medicine, 2016, 375(18):1767-1778. 2019金秋十月第二届抗体药产业发展大会 会议内容 时间:2019年10月19-20日 地点:上海(酒店待定) 规模:3...
最近在Nature communication上线了一篇标题为“PD-1 pathway regulates ILC2 metabolism and PD-1 agonist treatment ameliorates airway hyperreactivity”的文章。该文的通讯作者是来自美国南加州大学凯克医学院分子微生物学与免疫学学系的Omid Akbari。 过敏性哮喘是一种与呼吸系统症状有关的慢性疾病,如呼吸短促、胸闷和...
7.Helou DG, Shafiei-Jahani P, Lo R, Howard E, Hurrell BP, Galle-Treger L, Painter JD, Lewis G, Soroosh P, Sharpe AH et al: PD-1 pathway regulates ILC2 metabolism and PD-1 agonist treatment ameliorates airway hyperreactivity. Nat Commun 2020, 11(1):3998. ...
最终,相关论文以《PD-L1/PD-1 检查点通路调节海马神经元兴奋性与学习记忆行为》(PD-L1/PD-1 checkpoint pathway regulates hippocampal neuronal excitability and learning and memory behavior)为题发在Neuron(IF 16.2),赵俊利博士是第一作者,纪如荣担任通讯作者[1]。
[4] Zhan MM, Hu XQ, Liu XX, Ruan BF, Xu J, Liao C. From monoclonal antibodies to small molecules: the development of inhibitors targeting the PD-1/PD-L1 pathway. Drug Discov Today. 2016;21(6):1027-1036. doi:10.1016/j.drudis.2016.04.011 ...
2023年6月21日，纪如荣研究团队（赵俊利博士为第一作者）在Neuron杂志在线发表了题为“PD-L1/PD-1 checkpoint pathway regulates hippocampal neuronal excitability and learning and memory behavior”的研究论文【6】。该研究发现脑内的PD-L1/PD-1免疫检查点通路在学习记忆调控中发挥重要作：降低脑内PD-L1/PD-1...
针对“难题一”,君实根据病人的免疫微环境特点设计了多元化的联合治疗,如联合BTLA、TIGIT、CD112R等通路,旨在阻断患者或适应症特异的并行抑制性通路,实现“免疫正常化”。“PD-1就像一个‘普遍通路’(universalpathway),未来,I-O药物+PD-1抗体的多阻断将成为免疫治疗不可或缺的组成部分。”姚盛说。