Patsoukis N,Brown J,Petkova V,et al.Selective effects of PD-1 on Akt and Raspathways regulate molecular components of the cell cycle and inhibit T cell proliferation[J].Sci Signal,2012,5( 230) : ra46. Ketelhuth DF,Hansson GK.Adaptive response of T and B cells in atherosclerosis[J]. ...
信号传导与转录激活因子3(signal transducer and activator of transcription 3，STAT3)也参与PD-L1的表达，STAT3在多种肿瘤中PD-L1的表达中发挥关键作用[19]。Hippo信号通路中的Yes相关蛋白1(Yes-associated protein 1，YAP1)也与PD-L1的调节有关。Yan等[20]发现胰腺癌中双皮质素样激酶1(doublecortin-like kinase...
Upregulation of STING pathway inducible genes in MCA205‑mFAP tumors after treatment with177Lu‑FAP‑2287 and anti‑PD‑1 in vivo On day 8 pi, differential expression analysis to vehicle control showed177Lu...
PD-1/PD-L1 sig- nal pathway participates in HCV F protein-induced T cell dysfunc- tion in chronic HCV infection. Immunol Res. 2016;64(2):412-23. doi: 10.1007/s12026-015-8680-y. [PubMed: 26286967].XIAO W,JIANG LF,DENG XZ,et al. PD - 1 /PD - L1 signalpathway participates in ...
信号传导与转录激活因子3(signal transducer and activator of transcription 3,STAT3)也参与PD-L1的表达,STAT3在多种肿瘤中PD-L1的表达中发挥关键作用[19]。Hippo信号通路中的Yes相关蛋白1(Yes-associated protein 1,YAP1)也与PD-L1的调节有关。Yan等[20]发现...
whereas CTLA-4 coreceptors deliver a negative co-inhibitory signal. PD-1, like CTLA-4, belongs to the CD28 family and delivers a negative signal when it interacts with its ligands, PD-L1 (B7-H1 or CD274) and PD-L2 (B7-DC or CD273), which belong to the B7 family (Fig.1) [8–...
PD-L1 basically hacks the T cell scanning system by jamming the signal to parts of the T cell system, called PD-1, and B7.1. Think of PD-1 as the sensor, that is part of T cell scanning system, and B7.1 is like alarm that issues alert when sth is wrong. When PD-L1 hacks the...
Schematic of PD-1/PD-L1 proteins highlighting potential PTM sites on PD-1/PD-L1.aThe full-length PD-1 protein is divided into three segments: the ectodomain, transmembrane (TM), and a cytoplasmic region (CR). The ectodomain comprises the signal peptide (SP), N-loop, IgV domain, and st...
8. Corcoran, R. B. et al. BRAF gene amplification can promote acquired resistance to MEK inhibitors in cancer cells harboring the BRAF V600E mutation. Sci. Signal. 3, ra84 (2010).9. Ahronian, L. G. et al. Clinical acquired resistance to RAF inhibitor combinations in BRAF-mutant ...
He X, Ma W, Hu J, et al. Diverse structures and antihepatoma effect of sesquiterpenoid dimers from Artemisia eriopoda by AKT/STAT signaling pathway. Signal Transduct Target Ther. 2023;8(1):64. 往期好文推荐 1)Sci Transl Med:川楝素增强胶质母细胞瘤抗肿瘤免疫的直接作用靶点 ...