Ai L, Xu A, Xu J. Roles of PD-1/PD-L1 Pathway: Signaling, Cancer, and Beyond.Adv Exp Med Biol. 2020;1248:33-59. doi:10.1007/978-981-15-3266-5_3 Han Y, Liu D, Li L. PD-1/PD-L1 pathway: current researches in cancer.Am J Cancer Res. 2020;10(3):727-742. Published 2020...
[1] Han Y, Liu D, Li L. PD-1/PD-L1 pathway: current researches in cancer. Am J Cancer Res. 2020,10(3): 727-742. [2] Tang Q, Chen Y, Li X, et al. The role of PD-1/PD-L1 and application of immune-checkpoint inhibitors in human cancers. Front Imunol. 2022, 13: 964442...
2011年,哈佛大学Sharpe等人首次发现磺胺间甲氧嘧啶(sulfamonomethoxine)和磺胺甲噻二唑(sulfamethizole)能够抑制PD-1/PD-L1通路,以期用于治疗与PD-1/PD-L1 通路相关的疾病,如自身免疫性疾病、炎症性疾病、过敏、移植排斥、癌症、免疫缺陷等其他与免疫相关的疾病。这些化合物在0-10mmol /L 的浓度范围内具有抑制活性。
图1. PD-1/PD-L1信号通路 参考文献 1. Francisco L M., et al. The PD-1 pathway in tolerance and autoimmunity. Immunological Reviews.2010, 236: 219–42.2. Arlene H S., et al. The function of programmed cell death 1 and its ligands in regulating autoimmunity and infection. NATURE IMMUNO...
最近在Nature communication上线了一篇标题为“PD-1 pathway regulates ILC2 metabolism and PD-1 agonist treatment ameliorates airway hyperreactivity”的文章。该文的通讯作者是来自美国南加州大学凯克医学院分子微生物学与免疫学学系的Omid Akbari。 过敏性哮喘是一种与呼吸系统症状有关的慢性疾病,如呼吸短促、胸闷和...
【编者按】该视频以动画讲解的形式解析了肿瘤细胞通过表达PD-L1分子与T细胞表面的PD-1分子结合,抑制T细胞攻击肿瘤细胞的PDL1-PD1-Pathway,并针对这一信号通路来研发新药。 视频翻译: 作为一位科学家,我主要进行肿瘤免疫治疗的研究,我跟我的同事目前的主要工作就是找出能够...
图1.PD-1/PD-L1信号通路 参考文献 1. Francisco L M., et al. The PD-1 pathway in tolerance and autoimmunity. Immunological Reviews.2010, 236: 219–42. 2. Arlene H S., et al. The function of programmed cell death 1 and its ligands in regulating autoimmunity and infection. NATURE IMMUNO...
[3] Boussiotis V A. Molecular and Biochemical Aspects of the PD-1 Checkpoint Pathway[J]. New England Journal of Medicine, 2016, 375(18):1767-1778. 2019金秋十月第二届抗体药产业发展大会 会议内容 时间:2019年10月19-20日 地点:上海(酒店待定) ...
2. Tumeh, P. C. et al. PD-1 blockade induces responses by inhibiting adaptive immune resistance. Nature515, 568–571 (2014).3. Topalian, S. L., Drake, C. G. & Pardoll, D. M. Targeting the PD-1/B7-H1(PD-L1) pathway to activate anti-tumor immunity. Curr. Opin. Immunol.24,...
The PD-1 pathway in tolerance and autoimmunity. Immunol. Rev. 236:219-242. http:// dx.doi.org/10.1111/j.1600-065X.2010.00923.xFrancisco LM, Sage PT, Sharpe AH. The PD-1 path- way in tolerance and autoimmunity. Immunol Rev 2010; 236: 219-42.Francisco LM, Sage PT, Sharpe AH. ...