3. Garcia-Diaz, A. et al. Interferon Receptor Signaling Pathways Regulating PD-L1 and PD-L2 Expression. Cell reports 19, 1189-1201 (2017).4. Boussiotis, V.A. Molecular and Biochemical Aspects of the PD-1 Checkpoint Pathway. N Engl J Med 375, 1767-1778 (2016).5. Jiang, Y., Li, ...
PurposeTo identify radiosensitive genes in PD-L1 expression and PD-1 check point pathway in cancer.Methods and MaterialsGene expression datasets and information were downloaded from TCGA. Stepwise multivariate Cox regression based on AIC was performed using stacking multiple interpolation data to identify...
及不同抗体检测PD-L1表达一致性等几个方面进行深入解析:1)PD-L1在免疫细胞和肿瘤细胞中均会表达,PD-1/PD-L1抑制剂作用于T细胞效应阶段,且PD-1/PD-L1通路是调节T细胞的负性共刺激分子;2)目前4种PD-L1检测抗体/试剂盒均已获批,其中22C3、28-8、SP...
1.PD-L1信号通路概述 1.1 PD-1 及其配体的结构与分布 PD-1 属于免疫球蛋白超家族Ⅰ型跨膜糖蛋白,由人PDCD1基因编码,该基因位于染色体 2q37. 3位点,其相对分子质量约为55 000,是由288个氨基酸组成的细胞表面单…
Indeed, the PD-1/PD-L1 pathway governs the induction and maintenance of immune tolerance within the tumor microenvironment. Consequently, the regulation of PD-1/PD-L1 immune checkpoint expression is of paramount importance. This review summarizes the mechanisms governing PD1/PD-L1 expression at ...
在肿瘤微环境中,肿瘤细胞通过高表达PD-L1分子,与T细胞上的受体PD-1结合,传递负性调控信号,显著抑制T细胞的活化与增殖,并调节细胞因子的表达和分泌,使肿瘤细胞逃避机体的免疫监控和杀伤,促进肿瘤进展;而阻断该通路可以增强机体的内源性抗肿瘤免疫效应。...
(2) Hypoxia and chronic inflammation, which activate NF-KB, can also cause an increased expression of PD-1 and PD-L1 in MDSCs [63,116]. (3) S-100 A9 has also been implicated in the increased expression of PD-1 and PD-L1 in MDSCs in CLL [69], and, when CLL was treated with...
Even with recent advances in therapy regimen, multiple myeloma patients commonly develop drug resistance and relapse. The relevance of targeting the PD-1/PD-L1 axis has been demonstrated in pre-clinical models. Monotherapy with PD-1 inhibitors produced d
2022年1月27日，日本国立癌症研究中心Hiroyoshi Nishikawa教授领衔在Cancer Cell杂志发表了题为Lactic acid promotes PD-1 expression in regulatory T cells in highly glycolytic tumor microenvironments的研究长文，通过从代谢角度研究TME中表达PD-1的效应T细胞和Treg细胞间稳态平衡的影响因素，发现乳酸能够作为Treg细胞的...
近年来,肿瘤免疫治疗(Immunology Oncology Therapy)已成为晚期恶性肿瘤治疗的重要手段之一。肿瘤免疫治疗并不直接攻击癌细胞,而是通过激活人体自身免疫系统来抗击肿瘤,具有良好的安全性及耐受性。PD-1/L1 抗…