【编者按】该视频以动画讲解的形式解析了肿瘤细胞通过表达PD-L1分子与T细胞表面的PD-1分子结合,抑制T细胞攻击肿瘤细胞的PDL1-PD1-Pathway,并针对这一信号通路来研发新药。 视频翻译: 作为一位科学家,我主要进行肿瘤免疫治疗的研究,我跟我的同事目前的主要工作就是找出能够...
参考文献 1. Francisco L M., et al. The PD-1 pathway in tolerance and autoimmunity. Immunological Reviews.2010, 236: 219–42.2. Arlene H S., et al. The function of programmed cell death 1 and its ligands in regulating autoimmunity and infection. NATURE IMMUNOLOGY. 2007, 8: 239-245.3...
Zou W, Wolchok JD, Chen L. PD-L1 (B7-H1) and PD-1 pathway blockade for cancer therapy: Mechanisms, response biomarkers, and combinations. Sci Transl Med. 2016;8(328):328rv324. DOI: 10.1126/scitranslmed.aad7118 Kim JM, Chen DS. Immune escape to PD-L1/PD-1 blockade: seven steps ...
参考文献 1. Francisco L M., et al. The PD-1 pathway in tolerance and autoimmunity. Immunological Reviews.2010, 236: 219–42. 2. Arlene H S., et al. The function of programmed cell death 1 and its ligands in regulating autoimmunity and infection. NATURE IMMUNOLOGY. 2007, 8: 239-245....
[4].Kim C Ohaegbulam, Amer Assal, Eszter Lazar-Molnar, et al. Human cancer immunotherapy with antibodies to the PD-1 and PD-L1 pathway[J]. Trends Mol Med. 2015 Jan;21(1):24-33. [5].Maud Mayoux, Andreas Roller, Vesna ...
Ai L, Xu A, Xu J. Roles of PD-1/PD-L1 Pathway: Signaling, Cancer, and Beyond.Adv Exp Med Biol. 2020;1248:33-59. doi:10.1007/978-981-15-3266-5_3 Han Y, Liu D, Li L. PD-1/PD-L1 pathway: current researches in cancer.Am J Cancer Res. 2020;10(3):727-742. Published 2020...
最终,相关论文以《PD-L1/PD-1 检查点通路调节海马神经元兴奋性与学习记忆行为》(PD-L1/PD-1 checkpoint pathway regulates hippocampal neuronal excitability and learning and memory behavior)为题发在 Neuron(IF 16.2),赵俊利博士是第一作者,纪如荣担任通讯作者[1]。图 | 相关论文(来源:Neuron)另外,...
7.Jia, L., Q. Zhang, and R. Zhang, PD-1/PD-L1 pathway blockade works as an effective and practical therapy for cancer immunotherapy. Cancer Biol Med, 2018. 15(2): p. 116-123. 8.Joseph A Trapani, P.K.D., Immunotherapy of cancer. 2017. ...
8.Han Y, Liu D, LiL. PD-1/PD-L1 pathway: current researches in cancer. Am J Cancer Res. 2020 Mar1;10(3):727-742. PMID: 32266087; PMCID: PMC7136921. 9.Managingtoxicities associated with immune checkpoint inhibitors: consensusrecommendations from the Society for Immunotherapy of Cancer (...
7.Jia, L., Q. Zhang, and R. Zhang, PD-1/PD-L1 pathway blockade works as an effective and practical therapy for cancer immunotherapy.Cancer Biol Med, 2018. 15(2): p. 116-123. 8.Joseph A Trapani, P.K.D....